Reaction Details |
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Target | Transcription intermediary factor 1-alpha |
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Ligand | BDBM50150874 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1560318 (CHEMBL3779310) |
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IC50 | 2500±n/a nM |
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Citation | Palmer, WS; Poncet-Montange, G; Liu, G; Petrocchi, A; Reyna, N; Subramanian, G; Theroff, J; Yau, A; Kost-Alimova, M; Bardenhagen, JP; Leo, E; Shepard, HE; Tieu, TN; Shi, X; Zhan, Y; Zhao, S; Barton, MC; Draetta, G; Toniatti, C; Jones, P; Geck Do, M; Andersen, JN Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor. J Med Chem59:1440-54 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Transcription intermediary factor 1-alpha |
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Name: | Transcription intermediary factor 1-alpha |
Synonyms: | 6.3.2.- | E3 ubiquitin-protein ligase TRIM24 | RING finger protein 82 | RNF82 | RNF82 | TIF1 | TIF1-alpha | TIF1A | TIF1A_HUMAN | TRIM24 | Transcription intermediary factor 1-alpha | Tripartite motif-containing protein 24 |
Type: | PROTEIN |
Mol. Mass.: | 116839.55 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_107998 |
Residue: | 1050 |
Sequence: | MEVAVEKAVAAAAAASAAASGGPSAAPSGENEAESRQGPDSERGGEAARLNLLDTCAVCH
QNIQSRAPKLLPCLHSFCQRCLPAPQRYLMLPAPMLGSAETPPPVPAPGSPVSGSSPFAT
QVGVIRCPVCSQECAERHIIDNFFVKDTTEVPSSTVEKSNQVCTSCEDNAEANGFCVECV
EWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEAVGVTSQRPVFCPFHKKEQLKLYCETCDK
LTCRDCQLLEHKEHRYQFIEEAFQNQKVIIDTLITKLMEKTKYIKFTGNQIQNRIIEVNQ
NQKQVEQDIKVAIFTLMVEINKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVM
HFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTNNTIQFHCDPSFWAQNIINL
GSLVIEDKESQPQMPKQNPVVEQNSQPPSGLSSNQLSKFPTQISLAQLRLQHMQQQVMAQ
RQQVQRRPAPVGLPNPRMQGPIQQPSISHQQPPPRLINFQNHSPKPNGPVLPPHPQQLRY
PPNQNIPRQAIKPNPLQMAFLAQQAIKQWQISSGQGTPSTTNSTSSTPSSPTITSAAGYD
GKAFGSPMIDLSSPVGGSYNLPSLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSNRTVQS
PNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPI
RIKQENSGPPENYDFPVVIVKQESDEESRPQNANYPRSILTSLLLNSSQSSTSEETVLRS
DAPDSTGDQPGLHQDNSSNGKSEWLDPSQKSPLHVGETRKEDDPNEDWCAVCQNGGELLC
CEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLSKPEVEYDCDAPSHNSEKKKTEGLVKL
TPIDKRKCERLLLFLYCHEMSLAFQDPVPLTVPDYYKIIKNPMDLSTIKKRLQEDYSMYS
KPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKRFPKPEFRNESE
DNKFSDDSDDDFVQPRKKRLKSIEERQLLK
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BDBM50150874 |
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n/a |
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Name | BDBM50150874 |
Synonyms: | CHEMBL3775559 |
Type | Small organic molecule |
Emp. Form. | C18H20N2O5S |
Mol. Mass. | 376.427 |
SMILES | COc1ccc(c(OC)c1)S(=O)(=O)Nc1ccc2N(C)C(=O)CCc2c1 |
Structure |
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