Reaction Details |
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Target | Geranylgeranyl pyrophosphate synthase |
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Ligand | BDBM50151852 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1561702 (CHEMBL3777120) |
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IC50 | 380±n/a nM |
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Citation | Wills, VS; Allen, C; Holstein, SA; Wiemer, DF Potent Triazole Bisphosphonate Inhibitor of Geranylgeranyl Diphosphate Synthase. ACS Med Chem Lett6:1195-8 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Geranylgeranyl pyrophosphate synthase |
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Name: | Geranylgeranyl pyrophosphate synthase |
Synonyms: | Dimethylallyltranstransferase | Farnesyltranstransferase | GGPP synthetase | GGPPS_HUMAN | GGPPSase | GGPS1 | Geranylgeranyl Diphosphate Synthase (GGPPS) | Geranylgeranyl diphosphate synthase | Geranylgeranyl pyrophosphate synthetase | Geranyltranstransferase |
Type: | Homooctamer; transferase |
Mol. Mass.: | 34867.94 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human GGPPS was cloned and expressed in E. coli. |
Residue: | 300 |
Sequence: | MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS
LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL
ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL
GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN
IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
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BDBM50151852 |
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n/a |
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Name | BDBM50151852 |
Synonyms: | CHEMBL3775694 |
Type | Small organic molecule |
Emp. Form. | C20H31N3Na4O6P2 |
Mol. Mass. | 563.3832 |
SMILES | [Na+].[Na+].[Na+].[Na+].[#6]\[#6](-[#6])=[#6]/[#6]-[#6]\[#6](-[#6])=[#6]\[#6]C([#6]-c1cn(-[#6]-[#6]\[#6]=[#6](\[#6])-[#6])nn1)(P([#8-])([#8-])=O)P([#8-])([#8-])=O |
Structure |
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