| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-2 |
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| Ligand | BDBM50156373 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1570461 (CHEMBL3794688) |
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| Ki | 317±n/a nM |
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| Citation |  Nishiguchi, GA; Burger, MT; Han, W; Lan, J; Atallah, G; Tamez, V; Lindvall, M; Bellamacina, C; Garcia, P; Feucht, P; Zavorotinskaya, T; Dai, Y; Wong, K Design, synthesis and structure activity relationship of potent pan-PIM kinase inhibitors derived from the pyridyl carboxamide scaffold. Bioorg Med Chem Lett26:2328-32 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase pim-2 |
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| Name: | Serine/threonine-protein kinase pim-2 |
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| Synonyms: | PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2) |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 34185.93 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9P1W9 |
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| Residue: | 311 |
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| Sequence: | MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAI
KVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPL
PAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKL
IDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFER
DQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKG
GPAPLAWSLLP
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| BDBM50156373 |
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| n/a |
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| Name | BDBM50156373 |
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| Synonyms: | CHEMBL3793440 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H16FN5O |
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| Mol. Mass. | 385.3937 |
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| SMILES | Nc1ccc(nc1C(=O)Nc1cnccc1-c1ccncc1)-c1ccccc1F |
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| Structure | 
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