| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-glucuronidase |
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| Ligand | BDBM50160589 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1565959 (CHEMBL3790643) |
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| IC50 | 50280±n/a nM |
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| Citation |  Salar, U; Taha, M; Ismail, NH; Khan, KM; Imran, S; Perveen, S; Wadood, A; Riaz, M Thiadiazole derivatives as New Class of฿-glucuronidase inhibitors. Bioorg Med Chem24:1909-18 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-glucuronidase |
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| Name: | Beta-glucuronidase |
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| Synonyms: | Beta-glucuronidase | Beta-glucuronidase (β-glucuronidase) | EMBL:AAI33416.1 | Ensembl:ENSBTAP00000000941 | Ensembl:ENSBTAP00000000941} | GUSB |
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| Type: | Protein |
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| Mol. Mass.: | 74467.69 |
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| Organism: | Bos taurus (Bovine) |
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| Description: | EC 3.2.1.31, bovine liver |
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| Residue: | 652 |
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| Sequence: | MLRGSAGAWAVLGPLLWGCGLSLLQGGMLYPRESRSRERKELDGLWSFRADFSDNRRQGF
EQQWYRAPLRESGPTLDMPVPSSFNDVGQDGQLRSFVGWVWYEREITLPQRWTEDLGTRV
VLRIGSAHYYAIVWVNGVHVLEHEGGHLPFEADISKLVQSGPLSSCRITIAINNTLSPHT
LPPGTILYKTDPSMYPKGYFVQNTKFDFFNYAGLHRSVLLYTTPTTYIDDITVTTDMDQD
IGLVNYQIIVQGSDHFQVDVSLLDEEGKVMAKGAGAEGQLQVPSAHLWWPYLMHEHPAYL
YSLEVKLTAQTAVGPVSDFYTLPVGIRTVAVTKSQFLINGKPFYFRGVNKHEDADIRGKG
FDWPLLVKDFNLLRWLGANAFRTSHYPYSEEVLQLCDRYGIVVIDESPGVGIVLVESFSN
VSLQHHLEVMEEMIRRDKNHPAVVMWSLANEPASFLKPAGYYFKTLIAHTKALDPSRPVT
FVTNTNYEADLGAPYVDIICVNSYYSWYHDYGHMEVIQLQLATQFENWYKAYQKPMIQSE
YGADAIEGFHEDPPLMFSEEYQKGLLQQYHVVLDQKRKEYVVGELIWNFADFMTNQSPVR
MIGNRKGIFTRQRQPKSAAFLLRERYWKLANETRYQRSAVTSQCVGSGLFTV
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| BDBM50160589 |
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| n/a |
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| Name | BDBM50160589 |
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| Synonyms: | CHEMBL3786989 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H17N3O2S |
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| Mol. Mass. | 327.401 |
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| SMILES | COc1cc(OC)cc(c1)-c1nnc(Nc2ccc(C)cc2)s1 |
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| Structure | 
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