Reaction Details |
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Target | Proteasome subunit beta type-5 |
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Ligand | BDBM50163723 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1572440 (CHEMBL3796231) |
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IC50 | 25±n/a nM |
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Citation | Lei, M; Feng, H; Wang, C; Li, H; Shi, J; Wang, J; Liu, Z; Chen, S; Hu, S; Zhu, Y 3D-QSAR-aided design, synthesis, in vitro and in vivo evaluation of dipeptidyl boronic acid proteasome inhibitors and mechanism studies. Bioorg Med Chem24:2576-88 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Proteasome subunit beta type-5 |
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Name: | Proteasome subunit beta type-5 |
Synonyms: | 20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X |
Type: | Protein |
Mol. Mass.: | 28480.96 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 263 |
Sequence: | MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGT
TTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLAR
QCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRI
SGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVRE
DGWIRVSSDNVADLHEKYSGSTP
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BDBM50163723 |
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n/a |
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Name | BDBM50163723 |
Synonyms: | CHEMBL3793540 |
Type | Small organic molecule |
Emp. Form. | C23H23BCl2F6N2O4 |
Mol. Mass. | 587.147 |
SMILES | CC(C)C[C@H](NC(=O)[C@H](Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)NC(=O)c1cc(Cl)ccc1Cl)B(O)O |r| |
Structure |
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