Reaction Details |
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Target | Sphingosine 1-phosphate receptor 2 |
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Ligand | BDBM50165372 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1573253 (CHEMBL3803493) |
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EC50 | >1000±n/a nM |
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Citation | Lescop, C; Müller, C; Mathys, B; Birker, M; de Kanter, R; Kohl, C; Hess, P; Nayler, O; Rey, M; Sieber, P; Steiner, B; Weller, T; Bolli, MH Novel S1P1 receptor agonists - Part 4: Alkylaminomethyl substituted aryl head groups. Eur J Med Chem116:222-238 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sphingosine 1-phosphate receptor 2 |
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Name: | Sphingosine 1-phosphate receptor 2 |
Synonyms: | EDG5 | S1P2 | S1PR2 | S1PR2_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-5 | Sphingosine-1-phosphate receptor 2 | ndothelial differentiation G-protein coupled receptor 5 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 38883.16 |
Organism: | Homo sapiens (Human) |
Description: | Membranes isolated from S1P2-transfected CHO cells were used in ligand binding assay. |
Residue: | 353 |
Sequence: | MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVAR
NSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASV
FSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACS
TVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLG
VFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVL
RPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV
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BDBM50165372 |
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n/a |
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Name | BDBM50165372 |
Synonyms: | CHEMBL3798837 |
Type | Small organic molecule |
Emp. Form. | C27H38N4O5S |
Mol. Mass. | 530.679 |
SMILES | CCc1cc(cc(C)c1OC[C@@H](O)CNC(=O)CO)-c1noc(n1)-c1cc(C)c(CN(C)CC(C)C)s1 |r| |
Structure |
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