| Reaction Details |
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 | Report a problem with these data |
| Target | Glucagon receptor |
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| Ligand | BDBM50168097 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1575731 (CHEMBL3800951) |
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| IC50 | 8900±n/a nM |
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| Citation |  Shu, S; Cai, X; Li, J; Feng, Y; Dai, A; Wang, J; Yang, D; Wang, MW; Liu, H Design, synthesis, structure-activity relationships, and docking studies of pyrazole-containing derivatives as a novel series of potent glucagon receptor antagonists. Bioorg Med Chem24:2852-63 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glucagon receptor |
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| Name: | Glucagon receptor |
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| Synonyms: | GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54026.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P47871 |
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| Residue: | 477 |
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| Sequence: | MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNR
TFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQ
CQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANL
FASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYC
WLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDN
MGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGV
HEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRL
GKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
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| BDBM50168097 |
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| n/a |
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| Name | BDBM50168097 |
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| Synonyms: | CHEMBL3798135 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H22Cl2FN3O3 |
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| Mol. Mass. | 538.397 |
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| SMILES | OC(=O)CCNC(=O)c1ccc2C(CCc2c1)n1nc(cc1-c1ccc(F)cc1)-c1cc(Cl)cc(Cl)c1 |
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| Structure | 
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