| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-C |
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| Ligand | BDBM50105206 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1577630 (CHEMBL3807238) |
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| IC50 | 29±n/a nM |
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| Citation |  Koehler, MF; Bergeron, P; Blackwood, EM; Bowman, K; Clark, KR; Firestein, R; Kiefer, JR; Maskos, K; McCleland, ML; Orren, L; Salphati, L; Schmidt, S; Schneider, EV; Wu, J; Beresini, MH Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells. ACS Med Chem Lett7:223-8 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-C |
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| Name: | Cyclin-C |
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| Synonyms: | CCNC | CCNC_HUMAN | Cyclin C | SRB11 homolog | hSRB11 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 33244.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107900 |
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| Residue: | 283 |
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| Sequence: | MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQ
VIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRF
SYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIV
NDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQ
WKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
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| BDBM50105206 |
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| n/a |
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| Name | BDBM50105206 |
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| Synonyms: | 4-(4-Acetylamino-phenoxy)-thieno[2,3-c]pyridine-2-carboxylic acid amide | CHEMBL434222 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H13N3O3S |
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| Mol. Mass. | 327.358 |
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| SMILES | CC(=O)Nc1ccc(Oc2cncc3sc(cc23)C(N)=O)cc1 |
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| Structure | 
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