Compile Data Set for Download or QSAR

Found 100 hits with Last Name = 'firestein' and Initial = 'r'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-C (Homo sapiens (Human))	BDBM50265275 (4-(4-iodophenoxy)-2-(2H-tetrazol-5-yl)thieno[2,3-c...) Show SMILES Ic1ccc(Oc2cncc3sc(cc23)-c2nnn[nH]2)cc1 Show InChI InChI=1S/C14H8IN5OS/c15-8-1-3-9(4-2-8)21-11-6-16-7-13-10(11)5-12(22-13)14-17-19-20-18-14/h1-7H,(H,17,18,19,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50169081 (CHEMBL3806220) Show SMILES N#Cc1ccc(Oc2cncc3sc(cc23)-c2nnn[nH]2)cc1 Show InChI InChI=1S/C15H8N6OS/c16-6-9-1-3-10(4-2-9)22-12-7-17-8-14-11(12)5-13(23-14)15-18-20-21-19-15/h1-5,7-8H,(H,18,19,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50265311 (4-(4-chlorophenoxy)-2-(2H-tetrazol-5-yl)thieno[2,3...) Show SMILES Clc1ccc(Oc2cncc3sc(cc23)-c2nnn[nH]2)cc1 Show InChI InChI=1S/C14H8ClN5OS/c15-8-1-3-9(4-2-8)21-11-6-16-7-13-10(11)5-12(22-13)14-17-19-20-18-14/h1-7H,(H,17,18,19,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50169082 (CHEMBL3805960) Show SMILES FC(F)(F)Oc1ccc(Oc2cncc3sc(cc23)-c2nnn[nH]2)cc1 Show InChI InChI=1S/C15H8F3N5O2S/c16-15(17,18)25-9-3-1-8(2-4-9)24-11-6-19-7-13-10(11)5-12(26-13)14-20-22-23-21-14/h1-7H,(H,20,21,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50169062 (CHEMBL3805194) Show SMILES NC(=O)c1cc2c(Oc3ccc(Cl)cc3)cnc(N)c2s1 Show InChI InChI=1S/C14H10ClN3O2S/c15-7-1-3-8(4-2-7)20-10-6-18-13(16)12-9(10)5-11(21-12)14(17)19/h1-6H,(H2,16,18)(H2,17,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50265309 (2-(2H-tetrazol-5-yl)-4-(p-tolyloxy)thieno[2,3-c]py...) Show SMILES Cc1ccc(Oc2cncc3sc(cc23)-c2nnn[nH]2)cc1 Show InChI InChI=1S/C15H11N5OS/c1-9-2-4-10(5-3-9)21-12-7-16-8-14-11(12)6-13(22-14)15-17-19-20-18-15/h2-8H,1H3,(H,17,18,19,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50169080 (CHEMBL3806173) Show SMILES CC(=O)Nc1ccc(Oc2cncc3sc(cc23)-c2nnn[nH]2)cc1 Show InChI InChI=1S/C16H12N6O2S/c1-9(23)18-10-2-4-11(5-3-10)24-13-7-17-8-15-12(13)6-14(25-15)16-19-21-22-20-16/h2-8H,1H3,(H,18,23)(H,19,20,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50169078 (CHEMBL3804919) Show SMILES OC(=O)c1cc2c(Oc3ccc(Cl)cc3)cncc2s1 Show InChI InChI=1S/C14H8ClNO3S/c15-8-1-3-9(4-2-8)19-11-6-16-7-13-10(11)5-12(20-13)14(17)18/h1-7H,(H,17,18)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50264866 (4'-(2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin-4-ylo...) Show SMILES NC(=O)c1ccc(cc1)-c1ccc(Oc2cncc3sc(cc23)-c2nnn[nH]2)cc1 Show InChI InChI=1S/C21H14N6O2S/c22-20(28)14-3-1-12(2-4-14)13-5-7-15(8-6-13)29-17-10-23-11-19-16(17)9-18(30-19)21-24-26-27-25-21/h1-11H,(H2,22,28)(H,24,25,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
					More data for this Ligand-Target Pair
L-lactate dehydrogenase A chain (Homo sapiens (Human))	BDBM197160 (GNE-140 (6)) Show SMILES OC1=C(Sc2ccccc2Cl)C(=O)N[C@@](C1)(c1ccsc1)c1ccc(cc1)N1CCOCC1 |r,c:1| Show InChI InChI=1S/C25H23ClN2O3S2/c26-20-3-1-2-4-22(20)33-23-21(29)15-25(27-24(23)30,18-9-14-32-16-18)17-5-7-19(8-6-17)28-10-12-31-13-11-28/h1-9,14,16,29H,10-13,15H2,(H,27,30)/t25-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Genentech					Assay Description LDHA, LDHB, LDHC, MDH1 and MDH2 enzymatic assays have been described in detail previously [Dragovich, P.S. et al, Bioorg. Med. Chem. Lett. 24:3764-37...				Nat Chem Biol 12: 779-86 (2016) Article DOI: 10.1038/nchembio.2143 BindingDB Entry DOI: 10.7270/Q2W95800
					More data for this Ligand-Target Pair				3D Structure (crystal)
Cyclin-C (Homo sapiens (Human))	BDBM50532620 (CHEMBL4440347) Show SMILES FC(F)(F)c1cc(NC(=O)N[C@H]2CCN(C2)c2ccc3nncn3n2)ccc1Cl |r| Show InChI InChI=1S/C17H15ClF3N7O/c18-13-2-1-10(7-12(13)17(19,20)21)23-16(29)24-11-5-6-27(8-11)15-4-3-14-25-22-9-28(14)26-15/h1-4,7,9,11H,5-6,8H2,(H2,23,24,29)/t11-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of tracer236 from full-length His-tagged CDK8/cyclin C (unknown origin) incubated for 1 hr by TR-FRET analysis				ACS Med Chem Lett 7: 595-600 (2016) Article DOI: 10.1021/acsmedchemlett.6b00044 BindingDB Entry DOI: 10.7270/Q2XG9VN3
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50532620 (CHEMBL4440347) Show SMILES FC(F)(F)c1cc(NC(=O)N[C@H]2CCN(C2)c2ccc3nncn3n2)ccc1Cl |r| Show InChI InChI=1S/C17H15ClF3N7O/c18-13-2-1-10(7-12(13)17(19,20)21)23-16(29)24-11-5-6-27(8-11)15-4-3-14-25-22-9-28(14)26-15/h1-4,7,9,11H,5-6,8H2,(H2,23,24,29)/t11-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of tracer236 from full-length His-tagged CDK8/cyclin C (unknown origin) incubated for 1 hr by TR-FRET analysis				ACS Med Chem Lett 7: 595-600 (2016) Article DOI: 10.1021/acsmedchemlett.6b00044 BindingDB Entry DOI: 10.7270/Q2XG9VN3
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50169079 (CHEMBL3805857) Show SMILES NC(=O)c1ccc(Oc2cncc3sc(cc23)-c2nnn[nH]2)cc1 Show InChI InChI=1S/C15H10N6O2S/c16-14(22)8-1-3-9(4-2-8)23-11-6-17-7-13-10(11)5-12(24-13)15-18-20-21-19-15/h1-7H,(H2,16,22)(H,18,19,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
					More data for this Ligand-Target Pair
L-lactate dehydrogenase B chain (Homo sapiens (Human))	BDBM197160 (GNE-140 (6)) Show SMILES OC1=C(Sc2ccccc2Cl)C(=O)N[C@@](C1)(c1ccsc1)c1ccc(cc1)N1CCOCC1 |r,c:1| Show InChI InChI=1S/C25H23ClN2O3S2/c26-20-3-1-2-4-22(20)33-23-21(29)15-25(27-24(23)30,18-9-14-32-16-18)17-5-7-19(8-6-17)28-10-12-31-13-11-28/h1-9,14,16,29H,10-13,15H2,(H,27,30)/t25-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Genentech					Assay Description LDHA, LDHB, LDHC, MDH1 and MDH2 enzymatic assays have been described in detail previously [Dragovich, P.S. et al, Bioorg. Med. Chem. Lett. 24:3764-37...				Nat Chem Biol 12: 779-86 (2016) Article DOI: 10.1038/nchembio.2143 BindingDB Entry DOI: 10.7270/Q2W95800
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50105215 (4-(4-Cyano-phenoxy)-thieno[2,3-c]pyridine-2-carbox...) Show SMILES NC(=O)c1cc2c(Oc3ccc(cc3)C#N)cncc2s1 Show InChI InChI=1S/C15H9N3O2S/c16-6-9-1-3-10(4-2-9)20-12-7-18-8-14-11(12)5-13(21-14)15(17)19/h1-5,7-8H,(H2,17,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50169071 (CHEMBL3806024) Show SMILES CNC(=O)c1cc2c(Oc3ccc(I)cc3)cncc2s1 Show InChI InChI=1S/C15H11IN2O2S/c1-17-15(19)13-6-11-12(7-18-8-14(11)21-13)20-10-4-2-9(16)3-5-10/h2-8H,1H3,(H,17,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	5.30	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
					More data for this Ligand-Target Pair				3D Structure (crystal)
Cyclin-C (Homo sapiens (Human))	BDBM50169083 (CHEMBL3805667) Show SMILES Fc1ccc(Oc2cncc3sc(cc23)-c2nnn[nH]2)cc1 Show InChI InChI=1S/C14H8FN5OS/c15-8-1-3-9(4-2-8)21-11-6-16-7-13-10(11)5-12(22-13)14-17-19-20-18-14/h1-7H,(H,17,18,19,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50105170 (4-p-Tolyloxy-thieno[2,3-c]pyridine-2-carboxylic ac...) Show SMILES Cc1ccc(Oc2cncc3sc(cc23)C(N)=O)cc1 Show InChI InChI=1S/C15H12N2O2S/c1-9-2-4-10(5-3-9)19-12-7-17-8-14-11(12)6-13(20-14)15(16)18/h2-8H,1H3,(H2,16,18)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50105181 (4-(4-Chloro-phenoxy)-thieno[2,3-c]pyridine-2-carbo...) Show SMILES NC(=O)c1cc2c(Oc3ccc(Cl)cc3)cncc2s1 Show InChI InChI=1S/C14H9ClN2O2S/c15-8-1-3-9(4-2-8)19-11-6-17-7-13-10(11)5-12(20-13)14(16)18/h1-7H,(H2,16,18)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.20	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50169064 (CHEMBL3806134) Show SMILES Cc1ncc(Oc2ccc(Cl)cc2)c2cc(sc12)C(N)=O Show InChI InChI=1S/C15H11ClN2O2S/c1-8-14-11(6-13(21-14)15(17)19)12(7-18-8)20-10-4-2-9(16)3-5-10/h2-7H,1H3,(H2,17,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50105159 (4-(4-Chloro-phenoxy)-thieno[2,3-c]pyridine-2-carbo...) Show SMILES CNC(=O)c1cc2c(Oc3ccc(Cl)cc3)cncc2s1 Show InChI InChI=1S/C15H11ClN2O2S/c1-17-15(19)13-6-11-12(7-18-8-14(11)21-13)20-10-4-2-9(16)3-5-10/h2-8H,1H3,(H,17,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.20	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50265277 (4-phenoxy-2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin...) Show SMILES O(c1ccccc1)c1cncc2sc(cc12)-c1nnn[nH]1 Show InChI InChI=1S/C14H9N5OS/c1-2-4-9(5-3-1)20-11-7-15-8-13-10(11)6-12(21-13)14-16-18-19-17-14/h1-8H,(H,16,17,18,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.30	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50532615 (CHEMBL4549408) Show SMILES CCNc1nccc(n1)N1CC[C@@H](C1)NC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F |r| Show InChI InChI=1S/C18H20ClF3N6O/c1-2-23-16-24-7-5-15(27-16)28-8-6-12(10-28)26-17(29)25-11-3-4-14(19)13(9-11)18(20,21)22/h3-5,7,9,12H,2,6,8,10H2,1H3,(H,23,24,27)(H2,25,26,29)/t12-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.90	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of tracer236 from full-length His-tagged CDK8/cyclin C (unknown origin) incubated for 1 hr by TR-FRET analysis				ACS Med Chem Lett 7: 595-600 (2016) Article DOI: 10.1021/acsmedchemlett.6b00044 BindingDB Entry DOI: 10.7270/Q2XG9VN3
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50532615 (CHEMBL4549408) Show SMILES CCNc1nccc(n1)N1CC[C@@H](C1)NC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F |r| Show InChI InChI=1S/C18H20ClF3N6O/c1-2-23-16-24-7-5-15(27-16)28-8-6-12(10-28)26-17(29)25-11-3-4-14(19)13(9-11)18(20,21)22/h3-5,7,9,12H,2,6,8,10H2,1H3,(H,23,24,27)(H2,25,26,29)/t12-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.90	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of tracer236 from full-length His-tagged CDK8/cyclin C (unknown origin) incubated for 1 hr by TR-FRET analysis				ACS Med Chem Lett 7: 595-600 (2016) Article DOI: 10.1021/acsmedchemlett.6b00044 BindingDB Entry DOI: 10.7270/Q2XG9VN3
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50532614 (CHEMBL4566932) Show SMILES CNc1nccc(n1)N1CC[C@@H](C1)NC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F |r| Show InChI InChI=1S/C17H18ClF3N6O/c1-22-15-23-6-4-14(26-15)27-7-5-11(9-27)25-16(28)24-10-2-3-13(18)12(8-10)17(19,20)21/h2-4,6,8,11H,5,7,9H2,1H3,(H,22,23,26)(H2,24,25,28)/t11-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of tracer236 from full-length His-tagged CDK8/cyclin C (unknown origin) incubated for 1 hr by TR-FRET analysis				ACS Med Chem Lett 7: 595-600 (2016) Article DOI: 10.1021/acsmedchemlett.6b00044 BindingDB Entry DOI: 10.7270/Q2XG9VN3
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50532614 (CHEMBL4566932) Show SMILES CNc1nccc(n1)N1CC[C@@H](C1)NC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F |r| Show InChI InChI=1S/C17H18ClF3N6O/c1-22-15-23-6-4-14(26-15)27-7-5-11(9-27)25-16(28)24-10-2-3-13(18)12(8-10)17(19,20)21/h2-4,6,8,11H,5,7,9H2,1H3,(H,22,23,26)(H2,24,25,28)/t11-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of tracer236 from full-length His-tagged CDK8/cyclin C (unknown origin) incubated for 1 hr by TR-FRET analysis				ACS Med Chem Lett 7: 595-600 (2016) Article DOI: 10.1021/acsmedchemlett.6b00044 BindingDB Entry DOI: 10.7270/Q2XG9VN3
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50169067 (CHEMBL3805684) Show SMILES NC(=O)c1cc2c(Oc3ccc(Cl)cc3)cnc(Cl)c2s1 Show InChI InChI=1S/C14H8Cl2N2O2S/c15-7-1-3-8(4-2-7)20-10-6-18-13(16)12-9(10)5-11(21-12)14(17)19/h1-6H,(H2,17,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50169070 (CHEMBL3806182) Show SMILES NC(=O)c1cc2c(Oc3ccc(OC(F)(F)F)cc3)cncc2s1 Show InChI InChI=1S/C15H9F3N2O3S/c16-15(17,18)23-9-3-1-8(2-4-9)22-11-6-20-7-13-10(11)5-12(24-13)14(19)21/h1-7H,(H2,19,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50532619 (CHEMBL4568245) Show SMILES CCN1CCN(Cc2ccc(NC(=O)N[C@H]3CCN(C3)c3ccnc(NC)n3)cc2C(F)(F)F)CC1 |r| Show InChI InChI=1S/C24H33F3N8O/c1-3-33-10-12-34(13-11-33)15-17-4-5-18(14-20(17)24(25,26)27)30-23(36)31-19-7-9-35(16-19)21-6-8-29-22(28-2)32-21/h4-6,8,14,19H,3,7,9-13,15-16H2,1-2H3,(H,28,29,32)(H2,30,31,36)/t19-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of tracer236 from full-length His-tagged CDK8/cyclin C (unknown origin) incubated for 1 hr by TR-FRET analysis				ACS Med Chem Lett 7: 595-600 (2016) Article DOI: 10.1021/acsmedchemlett.6b00044 BindingDB Entry DOI: 10.7270/Q2XG9VN3
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50532628 (CHEMBL4461493) Show SMILES CNc1ncc(Oc2cccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2)c(N)n1 Show InChI InChI=1S/C19H16ClF3N6O2/c1-25-17-26-9-15(16(24)29-17)31-12-4-2-3-10(7-12)27-18(30)28-11-5-6-14(20)13(8-11)19(21,22)23/h2-9H,1H3,(H2,27,28,30)(H3,24,25,26,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of tracer236 from full-length His-tagged CDK8/cyclin C (unknown origin) incubated for 1 hr by TR-FRET analysis				ACS Med Chem Lett 7: 595-600 (2016) Article DOI: 10.1021/acsmedchemlett.6b00044 BindingDB Entry DOI: 10.7270/Q2XG9VN3
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50532619 (CHEMBL4568245) Show SMILES CCN1CCN(Cc2ccc(NC(=O)N[C@H]3CCN(C3)c3ccnc(NC)n3)cc2C(F)(F)F)CC1 |r| Show InChI InChI=1S/C24H33F3N8O/c1-3-33-10-12-34(13-11-33)15-17-4-5-18(14-20(17)24(25,26)27)30-23(36)31-19-7-9-35(16-19)21-6-8-29-22(28-2)32-21/h4-6,8,14,19H,3,7,9-13,15-16H2,1-2H3,(H,28,29,32)(H2,30,31,36)/t19-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of tracer236 from full-length His-tagged CDK8/cyclin C (unknown origin) incubated for 1 hr by TR-FRET analysis				ACS Med Chem Lett 7: 595-600 (2016) Article DOI: 10.1021/acsmedchemlett.6b00044 BindingDB Entry DOI: 10.7270/Q2XG9VN3
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50532628 (CHEMBL4461493) Show SMILES CNc1ncc(Oc2cccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2)c(N)n1 Show InChI InChI=1S/C19H16ClF3N6O2/c1-25-17-26-9-15(16(24)29-17)31-12-4-2-3-10(7-12)27-18(30)28-11-5-6-14(20)13(8-11)19(21,22)23/h2-9H,1H3,(H2,27,28,30)(H3,24,25,26,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of tracer236 from full-length His-tagged CDK8/cyclin C (unknown origin) incubated for 1 hr by TR-FRET analysis				ACS Med Chem Lett 7: 595-600 (2016) Article DOI: 10.1021/acsmedchemlett.6b00044 BindingDB Entry DOI: 10.7270/Q2XG9VN3
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50105153 (4-(4-Chloro-phenoxy)-thieno[2,3-c]pyridine-2-carbo...) Show SMILES CCNC(=O)c1cc2c(Oc3ccc(Cl)cc3)cncc2s1 Show InChI InChI=1S/C16H13ClN2O2S/c1-2-19-16(20)14-7-12-13(8-18-9-15(12)22-14)21-11-5-3-10(17)4-6-11/h3-9H,2H2,1H3,(H,19,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50169068 (CHEMBL3806291) Show SMILES NC(=O)c1cc2c(Oc3ccc(Cl)cc3)cnc(F)c2s1 Show InChI InChI=1S/C14H8ClFN2O2S/c15-7-1-3-8(4-2-7)20-10-6-18-13(16)12-9(10)5-11(21-12)14(17)19/h1-6H,(H2,17,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50532616 (CHEMBL4532382) Show SMILES CNc1nccc(n1)N1CC[C@@H](C1)NC(=O)Nc1ccc(CN2CCOCC2)c(c1)C(F)(F)F |r| Show InChI InChI=1S/C22H28F3N7O2/c1-26-20-27-6-4-19(30-20)32-7-5-17(14-32)29-21(33)28-16-3-2-15(18(12-16)22(23,24)25)13-31-8-10-34-11-9-31/h2-4,6,12,17H,5,7-11,13-14H2,1H3,(H,26,27,30)(H2,28,29,33)/t17-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of tracer236 from full-length His-tagged CDK8/cyclin C (unknown origin) incubated for 1 hr by TR-FRET analysis				ACS Med Chem Lett 7: 595-600 (2016) Article DOI: 10.1021/acsmedchemlett.6b00044 BindingDB Entry DOI: 10.7270/Q2XG9VN3
					More data for this Ligand-Target Pair				3D Structure (crystal)
Cyclin-C (Homo sapiens (Human))	BDBM50532616 (CHEMBL4532382) Show SMILES CNc1nccc(n1)N1CC[C@@H](C1)NC(=O)Nc1ccc(CN2CCOCC2)c(c1)C(F)(F)F |r| Show InChI InChI=1S/C22H28F3N7O2/c1-26-20-27-6-4-19(30-20)32-7-5-17(14-32)29-21(33)28-16-3-2-15(18(12-16)22(23,24)25)13-31-8-10-34-11-9-31/h2-4,6,12,17H,5,7-11,13-14H2,1H3,(H,26,27,30)(H2,28,29,33)/t17-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of tracer236 from full-length His-tagged CDK8/cyclin C (unknown origin) incubated for 1 hr by TR-FRET analysis				ACS Med Chem Lett 7: 595-600 (2016) Article DOI: 10.1021/acsmedchemlett.6b00044 BindingDB Entry DOI: 10.7270/Q2XG9VN3
					More data for this Ligand-Target Pair				3D Structure (crystal)
Cyclin-C (Homo sapiens (Human))	BDBM50532623 (CHEMBL4530828) Show SMILES CNc1nccc(n1)N1CC[C@@H](C1)NC(=O)Nc1ccc(C)c(Cl)c1 |r| Show InChI InChI=1S/C17H21ClN6O/c1-11-3-4-12(9-14(11)18)21-17(25)22-13-6-8-24(10-13)15-5-7-20-16(19-2)23-15/h3-5,7,9,13H,6,8,10H2,1-2H3,(H,19,20,23)(H2,21,22,25)/t13-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of tracer236 from full-length His-tagged CDK8/cyclin C (unknown origin) incubated for 1 hr by TR-FRET analysis				ACS Med Chem Lett 7: 595-600 (2016) Article DOI: 10.1021/acsmedchemlett.6b00044 BindingDB Entry DOI: 10.7270/Q2XG9VN3
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50532623 (CHEMBL4530828) Show SMILES CNc1nccc(n1)N1CC[C@@H](C1)NC(=O)Nc1ccc(C)c(Cl)c1 |r| Show InChI InChI=1S/C17H21ClN6O/c1-11-3-4-12(9-14(11)18)21-17(25)22-13-6-8-24(10-13)15-5-7-20-16(19-2)23-15/h3-5,7,9,13H,6,8,10H2,1-2H3,(H,19,20,23)(H2,21,22,25)/t13-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of tracer236 from full-length His-tagged CDK8/cyclin C (unknown origin) incubated for 1 hr by TR-FRET analysis				ACS Med Chem Lett 7: 595-600 (2016) Article DOI: 10.1021/acsmedchemlett.6b00044 BindingDB Entry DOI: 10.7270/Q2XG9VN3
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50532622 (CHEMBL4581368) Show SMILES FC(F)(F)c1cc(NC(=O)N[C@H]2CCN(C2)c2ccnc(NC3CC3)n2)ccc1Cl |r| Show InChI InChI=1S/C19H20ClF3N6O/c20-15-4-3-12(9-14(15)19(21,22)23)26-18(30)27-13-6-8-29(10-13)16-5-7-24-17(28-16)25-11-1-2-11/h3-5,7,9,11,13H,1-2,6,8,10H2,(H,24,25,28)(H2,26,27,30)/t13-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of tracer236 from full-length His-tagged CDK8/cyclin C (unknown origin) incubated for 1 hr by TR-FRET analysis				ACS Med Chem Lett 7: 595-600 (2016) Article DOI: 10.1021/acsmedchemlett.6b00044 BindingDB Entry DOI: 10.7270/Q2XG9VN3
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50532622 (CHEMBL4581368) Show SMILES FC(F)(F)c1cc(NC(=O)N[C@H]2CCN(C2)c2ccnc(NC3CC3)n2)ccc1Cl |r| Show InChI InChI=1S/C19H20ClF3N6O/c20-15-4-3-12(9-14(15)19(21,22)23)26-18(30)27-13-6-8-29(10-13)16-5-7-24-17(28-16)25-11-1-2-11/h3-5,7,9,11,13H,1-2,6,8,10H2,(H,24,25,28)(H2,26,27,30)/t13-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of tracer236 from full-length His-tagged CDK8/cyclin C (unknown origin) incubated for 1 hr by TR-FRET analysis				ACS Med Chem Lett 7: 595-600 (2016) Article DOI: 10.1021/acsmedchemlett.6b00044 BindingDB Entry DOI: 10.7270/Q2XG9VN3
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50532627 (CHEMBL4514427) Show SMILES CNc1nccc(n1)N1CC[C@@H](C1)NC(=O)Nc1ccc(CN2CCN(C)CC2)c(c1)C(F)(F)F |r| Show InChI InChI=1S/C23H31F3N8O/c1-27-21-28-7-5-20(31-21)34-8-6-18(15-34)30-22(35)29-17-4-3-16(19(13-17)23(24,25)26)14-33-11-9-32(2)10-12-33/h3-5,7,13,18H,6,8-12,14-15H2,1-2H3,(H,27,28,31)(H2,29,30,35)/t18-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of tracer236 from full-length His-tagged CDK8/cyclin C (unknown origin) incubated for 1 hr by TR-FRET analysis				ACS Med Chem Lett 7: 595-600 (2016) Article DOI: 10.1021/acsmedchemlett.6b00044 BindingDB Entry DOI: 10.7270/Q2XG9VN3
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50169069 (CHEMBL3806265) Show SMILES NC(=O)c1cc2c(Oc3ccc(cc3)C(N)=O)cncc2s1 Show InChI InChI=1S/C15H11N3O3S/c16-14(19)8-1-3-9(4-2-8)21-11-6-18-7-13-10(11)5-12(22-13)15(17)20/h1-7H,(H2,16,19)(H2,17,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50532627 (CHEMBL4514427) Show SMILES CNc1nccc(n1)N1CC[C@@H](C1)NC(=O)Nc1ccc(CN2CCN(C)CC2)c(c1)C(F)(F)F |r| Show InChI InChI=1S/C23H31F3N8O/c1-27-21-28-7-5-20(31-21)34-8-6-18(15-34)30-22(35)29-17-4-3-16(19(13-17)23(24,25)26)14-33-11-9-32(2)10-12-33/h3-5,7,13,18H,6,8-12,14-15H2,1-2H3,(H,27,28,31)(H2,29,30,35)/t18-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of tracer236 from full-length His-tagged CDK8/cyclin C (unknown origin) incubated for 1 hr by TR-FRET analysis				ACS Med Chem Lett 7: 595-600 (2016) Article DOI: 10.1021/acsmedchemlett.6b00044 BindingDB Entry DOI: 10.7270/Q2XG9VN3
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50169076 (CHEMBL3806114) Show SMILES Clc1ccc(Oc2cncc3sc(cc23)C(=O)NC2CC2)cc1 Show InChI InChI=1S/C17H13ClN2O2S/c18-10-1-5-12(6-2-10)22-14-8-19-9-16-13(14)7-15(23-16)17(21)20-11-3-4-11/h1-2,5-9,11H,3-4H2,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50105218 (4-(4-Methoxy-phenoxy)-thieno[2,3-c]pyridine-2-carb...) Show SMILES COc1ccc(Oc2cncc3sc(cc23)C(N)=O)cc1 Show InChI InChI=1S/C15H12N2O3S/c1-19-9-2-4-10(5-3-9)20-12-7-17-8-14-11(12)6-13(21-14)15(16)18/h2-8H,1H3,(H2,16,18)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50105206 (4-(4-Acetylamino-phenoxy)-thieno[2,3-c]pyridine-2-...) Show SMILES CC(=O)Nc1ccc(Oc2cncc3sc(cc23)C(N)=O)cc1 Show InChI InChI=1S/C16H13N3O3S/c1-9(20)19-10-2-4-11(5-3-10)22-13-7-18-8-15-12(13)6-14(23-15)16(17)21/h2-8H,1H3,(H2,17,21)(H,19,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50169073 (CHEMBL3805204) Show SMILES CCC(=O)c1cc2c(Oc3ccc(Cl)cc3)cncc2s1 Show InChI InChI=1S/C16H12ClNO2S/c1-2-13(19)15-7-12-14(8-18-9-16(12)21-15)20-11-5-3-10(17)4-6-11/h3-9H,2H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50169074 (CHEMBL3806037) Show SMILES CC(=O)c1cc2c(Oc3ccc(Cl)cc3)cncc2s1 Show InChI InChI=1S/C15H10ClNO2S/c1-9(18)14-6-12-13(7-17-8-15(12)20-14)19-11-4-2-10(16)3-5-11/h2-8H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc Curated by ChEMBL					Assay Description Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay				ACS Med Chem Lett 7: 223-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00278 BindingDB Entry DOI: 10.7270/Q29G5PPC
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM16673 (4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...) Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of tracer236 from full-length His-tagged CDK8/cyclin C (unknown origin) incubated for 1 hr by TR-FRET analysis				ACS Med Chem Lett 7: 595-600 (2016) Article DOI: 10.1021/acsmedchemlett.6b00044 BindingDB Entry DOI: 10.7270/Q2XG9VN3
					More data for this Ligand-Target Pair				3D Structure (crystal)
Cyclin-C (Homo sapiens (Human))	BDBM16673 (4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...) Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of tracer236 from full-length His-tagged CDK8/cyclin C (unknown origin) incubated for 1 hr by TR-FRET analysis				ACS Med Chem Lett 7: 595-600 (2016) Article DOI: 10.1021/acsmedchemlett.6b00044 BindingDB Entry DOI: 10.7270/Q2XG9VN3
					More data for this Ligand-Target Pair				3D Structure (crystal)

Displayed 1 to 50 (of 100 total )  |  Next  |  Last  >>

Jump to: