Reaction Details | |||
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Target | CREB-binding protein | ||
Ligand | BDBM50172113 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1579123 (CHEMBL3811651) | ||
Kd | 9800±n/a nM | ||
Citation | Unzue, A; Zhao, H; Lolli, G; Dong, J; Zhu, J; Zechner, M; Dolbois, A; Caflisch, A; Nevado, C The"Gatekeeper" Residue Influences the Mode of Binding of Acetyl Indoles to Bromodomains. J Med Chem59:3087-97 (2016) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
CREB-binding protein | |||
Name: | CREB-binding protein | ||
Synonyms: | CBP | CBP_HUMAN | CREB-binding protein (CBP) | CREB-binding protein (CREBBP) | CREBBP | ||
Type: | Transcription Coactivator | ||
Mol. Mass.: | 265411.66 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q92793 | ||
Residue: | 2442 | ||
Sequence: |
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BDBM50172113 | |||
n/a | |||
Name | BDBM50172113 | ||
Synonyms: | CHEMBL3809636 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H25N3O5 | ||
Mol. Mass. | 447.4831 | ||
SMILES | CCCOc1ccc2n(cc(-c3c(C)n([nH]c3=O)C(=O)c3ccc(OC)cc3)c2c1)C(C)=O |(-5.07,5.07,;-5.06,3.84,;-3.72,3.07,;-3.72,1.53,;-2.38,.77,;-2.38,-.77,;-1.03,-1.55,;.3,-.77,;1.76,-1.24,;2.66,.02,;1.76,1.24,;2.23,2.7,;3.72,3.05,;4.66,2.25,;3.83,4.58,;2.4,5.16,;1.41,3.98,;.18,4.06,;5.13,5.4,;6.22,4.82,;5.08,6.94,;6.38,7.76,;6.33,9.3,;4.97,10.02,;4.9,11.56,;3.81,12.13,;3.66,9.2,;3.72,7.66,;.3,.77,;-1.03,1.55,;2.24,-2.7,;1.42,-3.62,;3.45,-2.94,)| | ||
Structure |