| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium/nucleoside cotransporter 2 |
|---|
| Ligand | BDBM50172400 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1579902 (CHEMBL3813158) |
|---|
| IC50 | 3300±n/a nM |
|---|
| Citation |  Tatani, K; Hiratochi, M; Kikuchi, N; Kuramochi, Y; Watanabe, S; Yamauchi, Y; Itoh, F; Isaji, M; Shuto, S Identification of Adenine and Benzimidazole Nucleosides as Potent Human Concentrative Nucleoside Transporter 2 Inhibitors: Potential Treatment for Hyperuricemia and Gout. J Med Chem59:3719-31 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium/nucleoside cotransporter 2 |
|---|
| Name: | Sodium/nucleoside cotransporter 2 |
|---|
| Synonyms: | CNT2 | S28A2_HUMAN | SLC28A2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 71934.06 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1477251 |
|---|
| Residue: | 658 |
|---|
| Sequence: | MEKASGRQSIALSTVETGTVNPGLELMEKEVEPEGSKRTDAQGHSLGDGLGPSTYQRRSR
WPFSKARSFCKTHASLFKKILLGLLCLAYAAYLLAACILNFQRALALFVITCLVIFVLVH
SFLKKLLGKKLTRCLKPFENSRLRLWTKWVFAGVSLVGLILWLALDTAQRPEQLIPFAGI
CMFILILFACSKHHSAVSWRTVFSGLGLQFVFGILVIRTDLGYTVFQWLGEQVQIFLNYT
VAGSSFVFGDTLVKDVFAFQALPIIIFFGCVVSILYYLGLVQWVVQKVAWFLQITMGTTA
TETLAVAGNIFVGMTEAPLLIRPYLGDMTLSEIHAVMTGGFATISGTVLGAFIAFGVDAS
SLISASVMAAPCALASSKLAYPEVEESKFKSEEGVKLPRGKERNVLEAASNGAVDAIGLA
TNVAANLIAFLAVLAFINAALSWLGELVDIQGLTFQVICSYLLRPMVFMMGVEWTDCPMV
AEMVGIKFFINEFVAYQQLSQYKNKRLSGMEEWIEGEKQWISVRAEIITTFSLCGFANLS
SIGITLGGLTSIVPHRKSDLSKVVVRALFTGACVSLISACMAGILYVPRGAEADCVSFPN
TSFTNRTYETYMCCRGLFQSTSLNGTNPPSFSGPWEDKEFSAMALTNCCGFYNNTVCA
|
|
|
|---|
| BDBM50172400 |
|---|
| n/a |
|---|
| Name | BDBM50172400 |
|---|
| Synonyms: | CHEMBL3808970 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H28N6O7 |
|---|
| Mol. Mass. | 536.5365 |
|---|
| SMILES | COC(=O)COc1cc(CNc2nc3c(N)ncnc3n2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)ccc1-c1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
