| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Oxysterols receptor LXR-alpha |
|---|
| Ligand | BDBM50172505 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1581226 (CHEMBL3811012) |
|---|
| EC50 | 2000±n/a nM |
|---|
| Citation |  Stachel, SJ; Zerbinatti, C; Rudd, MT; Cosden, M; Suon, S; Nanda, KK; Wessner, K; DiMuzio, J; Maxwell, J; Wu, Z; Uslaner, JM; Michener, MS; Szczerba, P; Brnardic, E; Rada, V; Kim, Y; Meissner, R; Wuelfing, P; Yuan, Y; Ballard, J; Holahan, M; Klein, DJ; Lu, J; Fradera, X; Parthasarathy, G; Uebele, VN; Chen, Z; Li, Y; Li, J; Cooke, AJ; Bennett, DJ; Bilodeau, MT; Renger, J Identification and in Vivo Evaluation of Liver X Receptorß-Selective Agonists for the Potential Treatment of Alzheimer's Disease. J Med Chem59:3489-98 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Oxysterols receptor LXR-alpha |
|---|
| Name: | Oxysterols receptor LXR-alpha |
|---|
| Synonyms: | LXRA | Liver X Receptor alpha (LXR-alpha) | Liver X receptor alpha | Liver X receptor alpha (LXRA) | Liver X receptor alpha (NR1H3) | Liver X, LXR alpha | NR1H3 | NR1H3_HUMAN | Nuclear orphan receptor LXR-alpha | Nuclear receptor subfamily 1 group H member 3 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 50403.85 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q13133 |
|---|
| Residue: | 447 |
|---|
| Sequence: | MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEA
AEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKG
FFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLK
RQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPM
APDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLL
ETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLI
AISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSV
HSEQVFALRLQDKKLPPLLSEIWDVHE
|
|
|
|---|
| BDBM50172505 |
|---|
| n/a |
|---|
| Name | BDBM50172505 |
|---|
| Synonyms: | CHEMBL3809555 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H35ClF3N3O3 |
|---|
| Mol. Mass. | 518.012 |
|---|
| SMILES | CC(C)[C@](O)(C(=O)N1CCC(CC1)C1CCN(CC1)c1ccc(C(=O)N(C)C)c(Cl)c1)C(F)(F)F |r| |
|---|
| Structure | 
|
|---|
Search and Browse
