Reaction Details |
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Target | Oxysterols receptor LXR-beta |
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Ligand | BDBM19993 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1581225 (CHEMBL3811011) |
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EC50 | 20±n/a nM |
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Citation | Stachel, SJ; Zerbinatti, C; Rudd, MT; Cosden, M; Suon, S; Nanda, KK; Wessner, K; DiMuzio, J; Maxwell, J; Wu, Z; Uslaner, JM; Michener, MS; Szczerba, P; Brnardic, E; Rada, V; Kim, Y; Meissner, R; Wuelfing, P; Yuan, Y; Ballard, J; Holahan, M; Klein, DJ; Lu, J; Fradera, X; Parthasarathy, G; Uebele, VN; Chen, Z; Li, Y; Li, J; Cooke, AJ; Bennett, DJ; Bilodeau, MT; Renger, J Identification and in Vivo Evaluation of Liver X Receptorß-Selective Agonists for the Potential Treatment of Alzheimer's Disease. J Med Chem59:3489-98 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Oxysterols receptor LXR-beta |
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Name: | Oxysterols receptor LXR-beta |
Synonyms: | LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 50978.79 |
Organism: | Homo sapiens (Human) |
Description: | P55055 |
Residue: | 460 |
Sequence: | MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDW
VIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA
RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQ
SQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKR
SFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQI
ALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMR
RLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRM
LMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
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BDBM19993 |
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n/a |
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Name | BDBM19993 |
Synonyms: | CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide | T 0901317 | T0901317 | TO-901317 | US10543183, Compound TO901317 | US10669296, Compound TO901317 | US10945978, Compound 1 | [3H]T0901317 |
Type | Small organic molecule |
Emp. Form. | C17H12F9NO3S |
Mol. Mass. | 481.333 |
SMILES | OC(c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c1ccccc1)(C(F)(F)F)C(F)(F)F |
Structure |
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