Reaction Details |
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Target | Cytochrome P450 3A4 |
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Ligand | BDBM50180844 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1584799 (CHEMBL3821882) |
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IC50 | >20000±n/a nM |
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Citation | Carosati, E; Cosimelli, B; Ioan, P; Severi, E; Katneni, K; Chiu, FC; Saponara, S; Fusi, F; Frosini, M; Matucci, R; Micucci, M; Chiarini, A; Spinelli, D; Budriesi, R Understanding Oxadiazolothiazinone Biological Properties: Negative Inotropic Activity versus Cytochrome P450-Mediated Metabolism. J Med Chem59:3340-52 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 3A4 |
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Name: | Cytochrome P450 3A4 |
Synonyms: | Albendazole monooxygenase | Albendazole sulfoxidase | CP3A4_HUMAN | CYP3A3 | CYP3A4 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 3A4 (CYP3A4) | Cytochrome P450 HLp | Nifedipine oxidase | Quinine 3-monooxygenase | Taurochenodeoxycholate 6-alpha-hydroxylase |
Type: | Enzyme |
Mol. Mass.: | 57349.57 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 503 |
Sequence: | MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF
DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI
AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS
MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV
FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI
IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV
NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS
KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG
GLLQPEKPVVLKVESRDGTVSGA
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BDBM50180844 |
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n/a |
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Name | BDBM50180844 |
Synonyms: | CHEMBL3818560 |
Type | Small organic molecule |
Emp. Form. | C18H16N2O4S |
Mol. Mass. | 356.396 |
SMILES | CCOC1(Sc2ccccc2-n2c1noc2=O)c1ccc(OC)cc1 |
Structure |
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