| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PAK 1 |
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| Ligand | BDBM50181452 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1584620 |
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| Ki | 11±n/a nM |
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| Citation |  Rudolph, J; Murray, LJ; Ndubaku, CO; O'Brien, T; Blackwood, E; Wang, W; Aliagas, I; Gazzard, L; Crawford, JJ; Drobnick, J; Lee, W; Zhao, X; Hoeflich, KP; Favor, DA; Dong, P; Zhang, H; Heise, CE; Oh, A; Ong, CC; La, H; Chakravarty, P; Chan, C; Jakubiak, D; Epler, J; Ramaswamy, S; Vega, R; Cain, G; Diaz, D; Zhong, Y Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window. J Med Chem59:5520-41 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase PAK 1 |
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| Name: | Serine/threonine-protein kinase PAK 1 |
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| Synonyms: | 2.7.11.1 | Alpha-PAK | Cell division control protein 42 homolog | PAK 1/CDC42 | PAK-1 | PAK1 | PAK1_HUMAN | Serine/threonine-protein kinase PAK 1/PAK 2/PAK 3 | p21-activated kinase 1 | p65-PAK |
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| Type: | n/a |
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| Mol. Mass.: | 60640.15 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13153 |
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| Residue: | 545 |
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| Sequence: | MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILP
GDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKN
PQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDD
DDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTE
KQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQ
MNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC
MDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSK
RSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNG
TPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEA
TKNNH
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| BDBM50181452 |
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| n/a |
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| Name | BDBM50181452 |
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| Synonyms: | CHEMBL3819118 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H27ClN6O3 |
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| Mol. Mass. | 506.984 |
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| SMILES | CCc1cccn(-c2ccc(c(Cl)c2)-c2cc3cnc(NC)nc3n(C[C@H]3CNCCO3)c2=O)c1=O |r| |
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| Structure | 
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