| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PAK 2 |
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| Ligand | BDBM50182294 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1584629 (CHEMBL3820957) |
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| Ki | 21±n/a nM |
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| Citation |  Rudolph, J; Murray, LJ; Ndubaku, CO; O'Brien, T; Blackwood, E; Wang, W; Aliagas, I; Gazzard, L; Crawford, JJ; Drobnick, J; Lee, W; Zhao, X; Hoeflich, KP; Favor, DA; Dong, P; Zhang, H; Heise, CE; Oh, A; Ong, CC; La, H; Chakravarty, P; Chan, C; Jakubiak, D; Epler, J; Ramaswamy, S; Vega, R; Cain, G; Diaz, D; Zhong, Y Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window. J Med Chem59:5520-41 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase PAK 2 |
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| Name: | Serine/threonine-protein kinase PAK 2 |
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| Synonyms: | PAK2 | PAK2_HUMAN | Serine/threonine-protein kinase PAK 1/PAK 2/PAK 3 | Serine/threonine-protein kinase PAK 2 | Serine/threonine-protein kinase PAK 2 (PAK2) | p21-Activated kinase 2 (PAK2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 58037.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13177 |
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| Residue: | 524 |
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| Sequence: | MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRHKIISIFSGT
EKGSKKKEKERPEISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNP
QAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPALNAKGTEAPAVVTEEEDDDEETAP
PVIAPRPDHTKSIYTRSVIDPVPAPVGDSHVDGAAKSLDKQKKKTKMTDEEIMEKLRTIV
SIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKE
LKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLH
ANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAY
GPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRC
LEMDVEKRGSAKELLQHPFLKLAKPLSSLTPLIMAAKEAMKSNR
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| BDBM50182294 |
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| n/a |
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| Name | BDBM50182294 |
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| Synonyms: | CHEMBL3817984 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H22ClN5O3 |
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| Mol. Mass. | 463.916 |
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| SMILES | CCn1c2nc(NC3COC3)ncc2cc(-c2ccc(cc2Cl)-n2cccc(C)c2=O)c1=O |
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| Structure | 
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