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TargetSerine/threonine-protein kinase RIPK2
LigandBDBM50184727
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1587102
IC50 8.0±n/a nM
Citation Haile PAVotta BJMarquis RWBury MJMehlmann JFSinghaus RCharnley AKLakdawala ASConvery MALipshutz DBDesai BMSwift BCapriotti CABerger SBMahajan MKReilly MARivera EJSun HHNagilla RBeal AMFinger JNCook MNKing BWOuellette MTTotoritis RDPierdomenico MNegroni AStronati LCucchiara SZiólkowski BVossenkämper AMacDonald TTGough PJBertin JCasillas LN The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase. J Med Chem 59:4867-80 (2016) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase RIPK2
Name:Serine/threonine-protein kinase RIPK2
Synonyms:Tyrosine-protein kinase RIPK2 | receptor-interacting serine/threonine-protein kinase 2
Type:Protein
Mol. Mass.:61201.30
Organism:Homo sapiens (Human)
Description:n/a
Residue:540
Sequence:
MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSER
KDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPL
RFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRS
SKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMY
SVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEI
TFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPET
SRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIIN
PLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTK
PTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
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  Blast E-value cutoff:
BDBM50184727
n/a
NameBDBM50184727
Synonyms:CHEMBL3822938
TypeSmall organic molecule
Emp. Form.C17H13F3N2O
Mol. Mass.318.2931
SMILESCc1ccc(O)cc1Nc1ccnc2ccc(cc12)C(F)(F)F
Structure
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