Reaction Details |
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Target | Translocator protein |
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Ligand | BDBM50186098 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1587255 (CHEMBL3826071) |
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Ki | >10000±n/a nM |
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Citation | Li, J; Schulte, ML; Nickels, ML; Manning, HC New structure-activity relationships of N-acetamide substituted pyrazolopyrimidines as pharmacological ligands of TSPO. Bioorg Med Chem Lett26:3472-7 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Translocator protein |
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Name: | Translocator protein |
Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo |
Type: | Mitochondrion membrane protein |
Mol. Mass.: | 18945.84 |
Organism: | Rattus norvegicus (rat) |
Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. |
Residue: | 169 |
Sequence: | MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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BDBM50186098 |
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n/a |
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Name | BDBM50186098 |
Synonyms: | CHEMBL3822812 |
Type | Small organic molecule |
Emp. Form. | C27H30N4O2 |
Mol. Mass. | 442.5527 |
SMILES | CCN(C(=O)Cc1c(nn2c(CC)cc(CC)nc12)-c1ccc(OC)cc1)c1ccccc1 |
Structure |
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