| Reaction Details |
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 | Report a problem with these data |
| Target | Urease |
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| Ligand | BDBM50187562 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1590361 (CHEMBL3830509) |
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| IC50 | 1340±n/a nM |
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| Citation |  Rauf, MK; Zaib, S; Talib, A; Ebihara, M; Badshah, A; Bolte, M; Iqbal, J Solution-phase microwave assisted parallel synthesis, biological evaluation and in silico docking studies of N,N'-disubstituted thioureas derived from 3-chlorobenzoic acid. Bioorg Med Chem24:4452-4463 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Urease |
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| Name: | Urease |
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| Synonyms: | UREA_CANEN | Urea amidohydrolase |
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| Type: | Enzyme |
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| Mol. Mass.: | 90746.20 |
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| Organism: | Canavalia ensiformis (Jack bean) (Horse bean) |
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| Description: | P07374 |
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| Residue: | 840 |
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| Sequence: | MKLSPREVEKLGLHNAGYLAQKRLARGVRLNYTEAVALIASQIMEYARDGEKTVAQLMCL
GQHLLGRRQVLPAVPHLLNAVQVEATFPDGTKLVTVHDPISRENGELQEALFGSLLPVPS
LDKFAETKEDNRIPGEILCEDECLTLNIGRKAVILKVTSKGDRPIQVGSHYHFIEVNPYL
TFDRRKAYGMRLNIAAGTAVRFEPGDCKSVTLVSIEGNKVIRGGNAIADGPVNETNLEAA
MHAVRSKGFGHEEEKDASEGFTKEDPNCPFNTFIHRKEYANKYGPTTGDKIRLGDTNLLA
EIEKDYALYGDECVFGGGKVIRDGMGQSCGHPPAISLDTVITNAVIIDYTGIIKADIGIK
DGLIASIGKAGNPDIMNGVFSNMIIGANTEVIAGEGLIVTAGAIDCHVHYICPQLVYEAI
SSGITTLVGGGTGPAAGTRATTCTPSPTQMRLMLQSTDDLPLNFGFTGKGSSSKPDELHE
IIKAGAMGLKLHEDWGSTPAAIDNCLTIAEHHDIQINIHTDTLNEAGFVEHSIAAFKGRT
IHTYHSEGAGGGHAPDIIKVCGIKNVLPSSTNPTRPLTSNTIDEHLDMLMVCHHLDREIP
EDLAFAHSRIRKKTIAAEDVLNDIGAISIISSDSQAMGRVGEVISRTWQTADKMKAQTGP
LKCDSSDNDNFRIRRYIAKYTINPAIANGFSQYVGSVEVGKLADLVMWKPSFFGTKPEMV
IKGGMVAWADIGDPNASIPTPEPVKMRPMYGTLGKAGGALSIAFVSKAALDQRVNVLYGL
NKRVEAVSNVRKLTKLDMKLNDALPEITVDPESYTVKADGKLLCVSEATTVPLSRNYFLF
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| BDBM50187562 |
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| n/a |
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| Name | BDBM50187562 |
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| Synonyms: | CHEMBL3827593 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H9Cl3N2OS |
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| Mol. Mass. | 359.658 |
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| SMILES | Clc1cccc(c1)C(=O)NC(=S)Nc1ccc(Cl)cc1Cl |
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| Structure | 
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