| Reaction Details |
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 | Report a problem with these data |
| Target | Serine protease hepsin |
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| Ligand | BDBM50187711 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1589258 (CHEMBL3830286) |
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| IC50 | 5900±n/a nM |
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| Citation |  Subedi, M; Minn, I; Chen, J; Kim, Y; Ok, K; Jung, YW; Pomper, MG; Byun, Y Design, synthesis and biological evaluation of PSMA/hepsin-targeted heterobivalent ligands. Eur J Med Chem118:208-218 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine protease hepsin |
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| Name: | Serine protease hepsin |
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| Synonyms: | HEPS_HUMAN | HPN | Hepsin | Serine protease hepsin | TMPRSS1 | Transmembrane protease serine 11E | Transmembrane protease, serine 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 45016.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human deglycosylated hepsin was expressed in Pichia pastoris. |
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| Residue: | 417 |
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| Sequence: | MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSAD
ARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCV
DEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSL
RYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYH
GGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQ
YYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCE
DSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL
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| BDBM50187711 |
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| n/a |
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| Name | BDBM50187711 |
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| Synonyms: | CHEMBL3827463 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H16FN3O |
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| Mol. Mass. | 345.3696 |
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| SMILES | NC(=N)c1ccc2[nH]c(cc2c1)-c1cc(ccc1O)-c1ccc(F)cc1 |
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| Structure | 
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