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Target17-beta-hydroxysteroid dehydrogenase 14
LigandBDBM50189884
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1590441
Ki 7.0±n/a nM
Citation Bertoletti NBraun FLepage MMöller GAdamski JHeine AKlebe GMarchais-Oberwinkler S New Insights into Human 17ß-Hydroxysteroid Dehydrogenase Type 14: First Crystal Structures in Complex with a Steroidal Ligand and with a Potent Nonsteroidal Inhibitor. J Med Chem 59:6961-7 (2016) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
17-beta-hydroxysteroid dehydrogenase 14
Name:17-beta-hydroxysteroid dehydrogenase 14
Synonyms:17-beta-HSD 14 | 17-beta-hydroxysteroid dehydrogenase 14 | 17-beta-hydroxysteroid dehydrogenase DHRS10 | DHRS10 | Dehydrogenase/reductase SDR family member 10 | HSD17B14 | Retinal short-chain dehydrogenase/reductase retSDR3 | SDR3 | SDR47C1 | Short chain dehydrogenase/reductase family 47C member 1
Type:PROTEIN
Mol. Mass.:28316.15
Organism:Homo sapiens (Human)
Description:ChEMBL_114829
Residue:270
Sequence:
MATGTRYAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAVFIL
CDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYT
LTKLALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVN
CISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLASEANFCTG
IELLVTGGAELGYGCKASRSTPVDAPDIPS
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  Blast E-value cutoff:
BDBM50189884
n/a
NameBDBM50189884
Synonyms:CHEMBL3827618
TypeSmall organic molecule
Emp. Form.C18H12FNO4
Mol. Mass.325.2906
SMILESOc1ccc(cc1O)-c1cccc(n1)C(=O)c1ccc(F)c(O)c1
Structure
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