Reaction Details |
| Report a problem with these data |
Target | Beta-adrenergic receptor kinase 2 |
---|
Ligand | BDBM50191310 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEBML_1612836 |
---|
IC50 | 55500±n/a nM |
---|
Citation | Guccione, M; Ettari, R; Taliani, S; Da Settimo, F; Zappalą, M; Grasso, S G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitors: Current Trends and Future Perspectives. J Med Chem59:9277-9294 (2016) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Beta-adrenergic receptor kinase 2 |
---|
Name: | Beta-adrenergic receptor kinase 2 |
Synonyms: | ADRBK2 | ARBK2_BOVIN | Beta-ARK-2 | Beta-adrenergic receptor kinase 2 | G-protein-coupled receptor kinase 3 | GRK3 |
Type: | PROTEIN |
Mol. Mass.: | 79815.63 |
Organism: | Bos taurus |
Description: | ChEMBL_113448 |
Residue: | 688 |
Sequence: | MADLEAVLADVSYLMAMEKSKATPAARASKKIVLPEPSIRSVMQKYLEERHEITFDKIFN
QRIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLENEEDRLCRSRQIYDTYIMKELLSC
SHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGSIFQKFMESDKFTRFCQWKNV
ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER
IMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATE
IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPE
VLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMNVELPDVFSPE
LKSLLEGLLQRDVSKRLGCHGGSAQELKTHDFFRGIDWQHVYLQKYPPPLIPPRGEVNAA
DAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVAETVYEAVNADTDKIEARK
RAKNKQLGHEEDYALGRDCIVHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQSL
LTMEQIVSVEETQIKDKKCILLRIKGGKQFVLQCESDPEFVQWKKELTETFMEAQRLLRR
APKFLNKSRSAVVELSKPPLCHRNSNGL
|
|
|
BDBM50191310 |
---|
n/a |
---|
Name | BDBM50191310 |
Synonyms: | CHEMBL3971763 |
Type | Small organic molecule |
Emp. Form. | C94H148N24O27 |
Mol. Mass. | 2046.3255 |
SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)N)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(O)=O |r| |
Structure |
|