| Reaction Details |
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 | Report a problem with these data |
| Target | Rhodopsin kinase GRK1 |
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| Ligand | BDBM14052 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1612830 (CHEMBL3854630) |
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| IC50 | 794300±n/a nM |
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| Citation |  Guccione, M; Ettari, R; Taliani, S; Da Settimo, F; Zappalą, M; Grasso, S G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitors: Current Trends and Future Perspectives. J Med Chem59:9277-9294 (2016) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Rhodopsin kinase GRK1 |
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| Name: | Rhodopsin kinase GRK1 |
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| Synonyms: | G protein-coupled receptor kinase 1 | GRK1 | GRK1_BOVIN | RHOK | Rhodopsin kinase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 62931.24 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_116985 |
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| Residue: | 561 |
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| Sequence: | MDFGSLETVVANSAFIAARGSFDASSGPASRDRKYLARLKLPPLSKCEALRESLDLGFEG
MCLEQPIGKRLFQQFLRTHEQHGPALQLWKDIEDYDTADDALRPQKAQALRAAYLEPQAQ
LFCSFLDAETVARARAGAGDGLFQPLLRAVLAHLGQAPFQEFLDSLYFLRFLQWKWLEAQ
PMGEDWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILA
KVHSRFIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVS
GLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPEL
LLGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPDKFSPAS
KDFCEALLQKDPEKRLGFRDGSCDGLRTHPLFRDISWRQLEAGMLTPPFVPDSRTVYAKN
IQDVGAFSTVKGVAFEKADTEFFQEFASGTCPIPWQEEMIETGVFGDLNVWRPDGQMPDD
MKGVSGQEAAPSSKSGMCVLS
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| BDBM14052 |
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| n/a |
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| Name | BDBM14052 |
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| Synonyms: | N-(1H-indazol-5-yl)-2-methyl-4-(naphthalen-2-yl)-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxamide | dihydropyridone indazole amide 12 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H20N4O2 |
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| Mol. Mass. | 396.4412 |
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| SMILES | CC1=C(C(CC(=O)N1)c1ccc2ccccc2c1)C(=O)Nc1ccc2[nH]ncc2c1 |t:1| |
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| Structure | 
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