| Reaction Details |
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 | Report a problem with these data |
| Target | G1/S-specific cyclin-D2 |
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| Ligand | BDBM6309 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1614396 (CHEMBL3856465) |
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| IC50 | 15±n/a nM |
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| Citation |  Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A Cyclin Dependent Kinase 9 Inhibitors for Cancer Therapy. J Med Chem59:8667-8684 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| G1/S-specific cyclin-D2 |
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| Name: | G1/S-specific cyclin-D2 |
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| Synonyms: | CCND2 | CCND2_HUMAN | CDK6/cyclin D2 | G1/S-specific cyclin-D2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 33058.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_108400 |
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| Residue: | 289 |
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| Sequence: | MELLCHEVDPVRRAVRDRNLLRDDRVLQNLLTIEERYLPQCSYFKCVQKDIQPYMRRMVA
TWMLEVCEEQKCEEEVFPLAMNYLDRFLAGVPTPKSHLQLLGAVCMFLASKLKETSPLTA
EKLCIYTDNSIKPQELLEWELVVLGKLKWNLAAVTPHDFIEHILRKLPQQREKLSLIRKH
AQTFIALCATDFKFAMYPPSMIATGSVGAAICGLQQDEEVSSLTCDALTELLAKITNTDV
DCLKACQEQIEAVLLNSLQQYRQDQRDGSKSEDELDQASTPTDVRDIDL
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| BDBM6309 |
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| n/a |
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| Name | BDBM6309 |
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| Synonyms: | 6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one Hydrochloride | 8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one | Ibrance | PD 0332991 | Palbociclib | Pyrido-[2,3-d]-pyrimidin-7-one 43 | US10189849, PD0332991 | US10464927, Compound Palbociclib | US10626107, Example Palbociclib | US10696682, Compound PD0332991 | US10927120, PD0332991 | US9464092, PD0332991 | US9957276, PD0332991 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H29N7O2 |
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| Mol. Mass. | 447.5328 |
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| SMILES | CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O |
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| Structure | 
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