| Reaction Details |
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 | Report a problem with these data |
| Target | WD repeat-containing protein 5 |
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| Ligand | BDBM50195365 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1617717 (CHEMBL3859786) |
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| IC50 | >20±n/a nM |
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| Citation |  Li, DD; Wang, ZH; Chen, WL; Xie, YY; You, QD; Guo, XK Structure-based design of ester compounds to inhibit MLL complex catalytic activity by targeting mixed lineage leukemia 1 (MLL1)-WDR5 interaction. Bioorg Med Chem24:6109-6118 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| WD repeat-containing protein 5 |
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| Name: | WD repeat-containing protein 5 |
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| Synonyms: | BIG3 | WD repeat-containing protein 5 | WD repeat-containing protein 5 (WDR5) | WD repeat-containing protein 5 (WRD5) | WDR5 | WDR5_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 36597.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P61964 |
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| Residue: | 334 |
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| Sequence: | MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL
ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK
CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN
RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL
WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH
TDVVISTACHPTENIIASAALENDKTIKLWKSDC
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| BDBM50195365 |
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| n/a |
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| Name | BDBM50195365 |
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| Synonyms: | CHEMBL3943757 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H27FN4O3 |
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| Mol. Mass. | 414.4732 |
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| SMILES | CC(C)OC(=O)c1ccc(N2CCN(C)CC2)c(NC(=O)c2ccc(F)c(N)c2)c1 |
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| Structure | 
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