| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium/hydrogen exchanger 3 |
|---|
| Ligand | BDBM50196843 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1618862 (CHEMBL3861031) |
|---|
| IC50 | 0.200000±n/a nM |
|---|
| Citation |  Rackelmann, N; Matter, H; Englert, H; Follmann, M; Maier, T; Weston, J; Arndt, P; Heyse, W; Mertsch, K; Wirth, K; Bialy, L Discovery and Optimization of 1-Phenoxy-2-aminoindanes as Potent, Selective, and Orally Bioavailable Inhibitors of the Na J Med Chem59:8812-8829 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium/hydrogen exchanger 3 |
|---|
| Name: | Sodium/hydrogen exchanger 3 |
|---|
| Synonyms: | NHE3 | SL9A3_HUMAN | SLC9A3 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 92861.96 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_141050 |
|---|
| Residue: | 834 |
|---|
| Sequence: | MWGLGARGPDRGLLLALALGGLARAGGVEVEPGGAHGESGGFQVVTFEWAHVQDPYVIAL
WILVASLAKIGFHLSHKVTSVVPESALLIVLGLVLGGIVWAADHIASFTLTPTVFFFYLL
PPIVLDAGYFMPNRLFFGNLGTILLYAVVGTVWNAATTGLSLYGVFLSGLMGDLQIGLLD
FLLFGSLMAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFESFVALGGD
NVTGVDCVKGIVSFFVVSLGGTLVGVVFAFLLSLVTRFTKHVRIIEPGFVFIISYLSYLT
SEMLSLSAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASSAETIIFMFLGISAVN
PFIWTWNTAFVLLTLVFISVYRAIGVVLQTWLLNRYRMVQLEPIDQVVLSYGGLRGAVAF
ALVVLLDGDKVKEKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKVKRSEHREPRLNEKLH
GRAFDHILSAIEDISGQIGHNYLRDKWSHFDRKFLSRVLMRRSAQKSRDRILNVFHELNL
KDAISYVAEGERRGSLAFIRSPSTDNVVNVDFTPRSSTVEASVSYLLRENVSAVCLDMQS
LEQRRRSIRDAEDMVTHHTLQQYLYKPRQEYKHLYSRHELTPTEDEKQDREIFHRTMRKR
LESFKSTKLGLNQNKKAAKLYKRERAQKRRNSSIPNGKLPMESPAQNFTIKEKDLELSDT
EEPPNYDEEMSGGIEFLASVTKDTASDSPAGIDNPVFSPDEALDRSLLARLPPWLSPGET
VVPSQRARTQIPYSPGTFCRLMPFRLSSKSVDSFLQADGPEERPPAALPESTHM
|
|
|
|---|
| BDBM50196843 |
|---|
| n/a |
|---|
| Name | BDBM50196843 |
|---|
| Synonyms: | CHEMBL3904640 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H21Cl4N3O3S |
|---|
| Mol. Mass. | 525.276 |
|---|
| SMILES | N[C@@H]1CCCN(C1)[C@H]1Cc2c(cc(Cl)cc2Cl)[C@@H]1Oc1ccc(c(Cl)c1Cl)S(N)(=O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
