| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin E synthase |
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| Ligand | BDBM50029593 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1619471 (CHEMBL3861640) |
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| IC50 | 7.0±n/a nM |
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| Citation |  Park, EB; Kim, KJ; Jeong, HR; Lee, JK; Kim, HJ; Lee, HH; Lim, JW; Shin, JS; Koeberle, A; Werz, O; Lee, KT; Lee, JY Synthesis, structure determination, and biological evaluation of phenylsulfonyl hydrazide derivatives as potential anti-inflammatory agents. Bioorg Med Chem Lett26:5193-5197 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin E synthase |
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| Name: | Prostaglandin E synthase |
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| Synonyms: | 5.3.99.3 | Microsomal prostaglandin E synthase 1 | PTGES_MOUSE | Pges | Prostaglandin E synthase | Ptges | mPGES-1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 17293.88 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_104562 |
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| Residue: | 153 |
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| Sequence: | MPSPGLVMESGQVLPAFLLCSTLLVIKMYAVAVITGQMRLRKKAFANPEDALKRGGLQYY
RSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPLIAWIHFLVVLTGRVVHTVAYLG
KLNPRLRSGAYVLAQFSCFSMALQILWEVAHHL
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| BDBM50029593 |
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| n/a |
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| Name | BDBM50029593 |
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| Synonyms: | CHEMBL7162 | N-(2-(cyclohexyloxy)-4-nitrophenyl)methanesulfonamide | N-(2-Cyclohexyloxy-4-nitro-phenyl)-methanesulfonamide | N-(2-Cyclohexyloxy-4-nitro-phenyl)-methanesulfonamide(NS-398) | N-[2-(cyclohexyloxy)-4-nitrophenyl]methane sulfonamide | N-[2-(cyclohexyloxy)-4-nitrophenyl]methanesulfonamide | N-{2-(cyclohexyloxy)-4-[hydroxy(oxido)amino]phenyl}methanesulfonamide | NS-398 | NS398 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H18N2O5S |
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| Mol. Mass. | 314.357 |
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| SMILES | CS(=O)(=O)Nc1ccc(cc1OC1CCCCC1)[N+]([O-])=O |
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| Structure | 
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