Reaction Details |
| Report a problem with these data |
Target | Prostaglandin E synthase |
---|
Ligand | BDBM50135226 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1619471 (CHEMBL3861640) |
---|
IC50 | 60±n/a nM |
---|
Citation | Park, EB; Kim, KJ; Jeong, HR; Lee, JK; Kim, HJ; Lee, HH; Lim, JW; Shin, JS; Koeberle, A; Werz, O; Lee, KT; Lee, JY Synthesis, structure determination, and biological evaluation of phenylsulfonyl hydrazide derivatives as potential anti-inflammatory agents. Bioorg Med Chem Lett26:5193-5197 (2016) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Prostaglandin E synthase |
---|
Name: | Prostaglandin E synthase |
Synonyms: | 5.3.99.3 | Microsomal prostaglandin E synthase 1 | PTGES_MOUSE | Pges | Prostaglandin E synthase | Ptges | mPGES-1 |
Type: | PROTEIN |
Mol. Mass.: | 17293.88 |
Organism: | Mus musculus |
Description: | ChEMBL_104562 |
Residue: | 153 |
Sequence: | MPSPGLVMESGQVLPAFLLCSTLLVIKMYAVAVITGQMRLRKKAFANPEDALKRGGLQYY
RSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPLIAWIHFLVVLTGRVVHTVAYLG
KLNPRLRSGAYVLAQFSCFSMALQILWEVAHHL
|
|
|
BDBM50135226 |
---|
n/a |
---|
Name | BDBM50135226 |
Synonyms: | CHEMBL3747473 |
Type | Small organic molecule |
Emp. Form. | C27H24N2O6S |
Mol. Mass. | 504.554 |
SMILES | COc1ccc(cc1)S(=O)(=O)N(Nc1ccccc1)C(=O)Oc1ccc(OCc2ccccc2)cc1 |
Structure |
|