Ki Summary

Reaction Details

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Target

Carboxypeptidase B2

Ligand

BDBM50197529

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_1619507

IC50

>30000±n/a nM

Citation

Halland, N; Czech, J; Czechtizky, W; Evers, A; Follmann, M; Kohlmann, M; Schreuder, HA; Kallus, C Sulfamide as Zinc Binding Motif in Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa). J Med Chem59:9567-9573 (2016) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Carboxypeptidase B2

Name:

Carboxypeptidase B2

Synonyms:

Type:

Enzyme

Mol. Mass.:

48432.74

Organism:

Homo sapiens (Human)

Description:

Q96IY4

Residue:

423

Sequence:

MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTAD
LIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYY
EQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGI
HAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRK
NRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNI
NQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSE
TLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVI
RNV

BDBM50197529

n/a

Name

BDBM50197529

Synonyms:

CHEMBL3944308

Type

Small organic molecule

Emp. Form.

C28H50N4O5S

Mol. Mass.

554.785

SMILES

CC1(C)[C@@H]2CC[C@@]1(C)[C@H](C2)NC(=O)[C@H](CC1CCCCC1)NS(=O)(=O)N[C@@H](CC1CCC(N)CC1)C(O)=O |r,wU:13.15,3.2,6.7,wD:26.29,8.11,THB:10:8:5.4:1,(19.19,-13.84,;19.2,-15.38,;17.7,-15.78,;20.04,-16.52,;19.39,-17.68,;19.32,-18.96,;20.22,-17.79,;20.62,-19.27,;21.62,-17.83,;21.61,-16.65,;22.96,-18.59,;24.29,-17.83,;24.29,-16.28,;25.63,-18.59,;25.63,-20.14,;24.29,-20.91,;22.96,-20.1,;21.62,-20.87,;21.6,-22.41,;22.93,-23.2,;24.29,-22.44,;26.98,-17.82,;28.33,-18.6,;27.22,-19.69,;29.41,-19.69,;29.68,-17.83,;31.03,-18.6,;31.03,-20.15,;32.36,-20.92,;32.35,-22.46,;33.68,-23.23,;35.01,-22.46,;36.34,-23.24,;35.02,-20.92,;33.68,-20.14,;32.36,-17.84,;33.69,-18.6,;32.36,-16.29,)|

Structure