| Reaction Details |
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 | Report a problem with these data |
| Target | Carboxypeptidase B2 |
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| Ligand | BDBM50197568 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1619504 (CHEMBL3861673) |
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| IC50 | >30000±n/a nM |
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| Citation |  Halland, N; Czech, J; Czechtizky, W; Evers, A; Follmann, M; Kohlmann, M; Schreuder, HA; Kallus, C Sulfamide as Zinc Binding Motif in Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa). J Med Chem59:9567-9573 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carboxypeptidase B2 |
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| Name: | Carboxypeptidase B2 |
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| Synonyms: | CBPB2_HUMAN | CPB2 | CPU | Carboxypeptidase B2 | Carboxypeptidase B2 isoform A | Carboxypeptidase U | Plasma carboxypeptidase B | TAFI | Thrombin-activable fibrinolysis inhibitor | pCPB |
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| Type: | Enzyme |
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| Mol. Mass.: | 48432.74 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96IY4 |
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| Residue: | 423 |
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| Sequence: | MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTAD
LIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYY
EQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGI
HAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRK
NRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNI
NQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSE
TLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVI
RNV
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| BDBM50197568 |
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| n/a |
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| Name | BDBM50197568 |
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| Synonyms: | CHEMBL3972493 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H48N4O6S |
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| Mol. Mass. | 556.758 |
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| SMILES | CC(=O)NCCCC[C@H](NS(=O)(=O)N[C@@H](CC1CCCCC1)C(=O)N[C@H]1C[C@H]2CC[C@]1(C)C2(C)C)C(O)=O |r,TLB:24:25:29.28:32| |
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| Structure | 
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