Reaction Details | |||
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Target | Carboxypeptidase B2 | ||
Ligand | BDBM50197564 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1619504 (CHEMBL3861673) | ||
IC50 | 1700±n/a nM | ||
Citation | Halland, N; Czech, J; Czechtizky, W; Evers, A; Follmann, M; Kohlmann, M; Schreuder, HA; Kallus, C Sulfamide as Zinc Binding Motif in Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa). J Med Chem59:9567-9573 (2016) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Carboxypeptidase B2 | |||
Name: | Carboxypeptidase B2 | ||
Synonyms: | CBPB2_HUMAN | CPB2 | CPU | Carboxypeptidase B2 | Carboxypeptidase B2 isoform A | Carboxypeptidase U | Plasma carboxypeptidase B | TAFI | Thrombin-activable fibrinolysis inhibitor | pCPB | ||
Type: | Enzyme | ||
Mol. Mass.: | 48432.74 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q96IY4 | ||
Residue: | 423 | ||
Sequence: |
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BDBM50197564 | |||
n/a | |||
Name | BDBM50197564 | ||
Synonyms: | CHEMBL3927290 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H48N4O5S | ||
Mol. Mass. | 516.737 | ||
SMILES | CC(C)(C)C1CCC(CC1)NC(=O)[C@H](CC1CCCCC1)NS(=O)(=O)N[C@@H](CCCCN)C(O)=O |r,wU:13.14,wD:26.28,(2.75,-7.11,;3.53,-5.79,;1.99,-5.78,;3.54,-4.25,;4.86,-6.57,;6.21,-5.81,;7.54,-6.58,;7.53,-8.13,;6.19,-8.9,;4.85,-8.12,;8.86,-8.91,;10.2,-8.14,;10.2,-6.6,;11.53,-8.91,;11.53,-10.45,;10.19,-11.21,;8.87,-10.43,;7.53,-11.18,;7.51,-12.72,;8.84,-13.51,;10.19,-12.75,;12.86,-8.14,;14.2,-8.91,;13.09,-9.99,;15.28,-9.99,;15.53,-8.14,;16.86,-8.91,;16.86,-10.45,;18.2,-11.22,;18.2,-12.76,;19.53,-13.53,;19.53,-15.07,;18.2,-8.14,;19.53,-8.91,;18.2,-6.6,)| | ||
Structure |