| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphatidylinositol 4-kinase type 2-alpha |
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| Ligand | BDBM50199888 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1621779 (CHEMBL3864062) |
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| IC50 | >10000±n/a nM |
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| Citation |  Mejdrová, I; Chalupská, D; Placková, P; Müller, C; ?ála, M; Klíma, M; Baumlová, A; Hrebabecký, H; Procházková, E; Dejmek, M; Strunin, D; Weber, J; Lee, G; Matou?ová, M; Mertlíková-Kaiserová, H; Ziebuhr, J; Birkus, G; Boura, E; Nencka, R Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIß (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology. J Med Chem60:100-118 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphatidylinositol 4-kinase type 2-alpha |
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| Name: | Phosphatidylinositol 4-kinase type 2-alpha |
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| Synonyms: | P4K2A_HUMAN | PI4K2A | Phosphatidylinositol 4-kinase type 2-alpha | Phosphatidylinositol 4-kinase type II-alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 54030.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_104812 |
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| Residue: | 479 |
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| Sequence: | MDETSPLVSPERAQPPDYTFPSGSGAHFPQVPGGAVRVAAAAGSGPSPPGSPGHDRERQP
LLDRARGAAAQGQTQTVAAQAQALAAQAAAAAHAAQAHRERNEFPEDPEFEAVVRQAELA
IERCIFPERIYQGSSGSYFVKDPQGRIIAVFKPKNEEPYGHLNPKWTKWLQKLCCPCCFG
RDCLVLNQGYLSEAGASLVDQKLELNIVPRTKVVYLASETFNYSAIDRVKSRGKRLALEK
VPKVGQRFNRIGLPPKVGSFQLFVEGYKDADYWLRRFEAEPLPENTNRQLLLQFERLVVL
DYIIRNTDRGNDNWLIKYDCPMDSSSSRDTDWVVVKEPVIKVAAIDNGLAFPLKHPDSWR
AYPFYWAWLPQAKVPFSQEIKDLILPKISDPNFVKDLEEDLYELFKKDPGFDRGQFHKQI
AVMRGQILNLTQALKDNKSPLHLVQMPPVIVETARSHQRSSSESYTQSFQSRKPFFSWW
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| BDBM50199888 |
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| n/a |
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| Name | BDBM50199888 |
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| Synonyms: | CHEMBL3976651 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H27ClN6O4S |
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| Mol. Mass. | 531.027 |
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| SMILES | CCc1cc(CNc2cc(Cl)nn3c(c(C)nc23)-c2ccc(OC)c(c2)S(=O)(=O)NCCO)ccn1 |
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| Structure | 
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