| Reaction Details |
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 | Report a problem with these data |
| Target | cGMP-dependent protein kinase |
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| Ligand | BDBM50446179 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1622707 (CHEMBL3865059) |
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| IC50 | 2220±n/a nM |
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| Citation |  Huang, W; Hulverson, MA; Zhang, Z; Choi, R; Hart, KJ; Kennedy, M; Vidadala, RSR; Maly, DJ; Van Voorhis, WC; Lindner, SE; Fan, E; Ojo, KK 5-Aminopyrazole-4-carboxamide analogues are selective inhibitors of Plasmodium falciparum microgametocyte exflagellation and potential malaria transmission blocking agents. Bioorg Med Chem Lett26:5487-5491 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| cGMP-dependent protein kinase |
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| Name: | cGMP-dependent protein kinase |
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| Synonyms: | n/a |
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| Type: | PROTEIN |
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| Mol. Mass.: | 97679.99 |
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| Organism: | Plasmodium falciparum |
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| Description: | ChEMBL_862297 |
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| Residue: | 853 |
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| Sequence: | MEEDDNLKKGNERNKKKAIFSNDDFTGEDSLMEDHLELREKLSEDIDMIKTSLKNNLVCS
TLNDNEILTLSNYMQFFVFKSGNLVIKQGEKGSYFFIINSGKFDVYVNDKKVKTMGKGSS
FGEAALIHNTQRSATIIAETDGTLWGVQRSTFRATLKQLSNRNFNENRTFIDSVSVFDML
TEAQKNMITNACVIQNFKSGETIVKQGDYGDVLYILKEGKATVYINDEEIRVLEKGSYFG
ERALLYDEPRSATIIAKEPTACASICRKLLNIVLGNLQVVLFRNIMTEALQQSEIFKQFS
GDQLNDLADTAIVRDYPANYNILHKDKVKSVKYIIVLEGKVELFLDDTSIGILSRGMSFG
DQYVLNQKQPFKHTIKSLEVCKIALITETCLADCLGNNNIDASIDYNNKKSIIKKMYIFR
YLTDKQCNLLIEAFRTTRYEEGDYIIQEGEVGSRFYIIKNGEVEIVKNKKRLRTLGKNDY
FGERALLYDEPRTASVISKVNNVECWFVDKSVFLQIIQGPMLAHLEERIKMQDTKVEMDE
LETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAENDHPF
IIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAIEYLHERNI
VYRDLKPENILLDKQGYVKLIDFGCAKKVQGRAYTLVGTPHYMAPEVILGKGYGCTVDIW
ALGICLYEFICGPLPFGNDEEDQLEIFRDILTGQLTFPDYVTDTDSINLMKRLLCRLPQG
RIGCSINGFKDIKDHPFFSNFNWDKLAGRLLDPPLVSKSETYAEDIDIKQIEEEDAEDDE
EPLNDEDNWDIDF
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| BDBM50446179 |
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| n/a |
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| Name | BDBM50446179 |
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| Synonyms: | CHEMBL3109011 | US9518026, Example 39 | US9956214, Compound 1517 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H23N5O2 |
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| Mol. Mass. | 353.4182 |
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| SMILES | CCOc1ccc2cc(cnc2c1)-c1nn(c(N)c1C(N)=O)C(C)(C)C |
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| Structure | 
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