| Reaction Details |
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 | Report a problem with these data |
| Target | DNA topoisomerase 1 |
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| Ligand | BDBM50203046 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1624945 (CHEMBL3867357) |
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| IC50 | 28400±n/a nM |
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| Citation |  Taghavi-Moghadam, S; Kwong, CD; Secrist, JA; Khan, SI; Clark, AM The synthesis and biological evaluation of alkyl and benzyl naphthyridinium analogs of eupolauridine as potential antimicrobial and cytotoxic agents. Bioorg Med Chem24:6119-6130 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA topoisomerase 1 |
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| Name: | DNA topoisomerase 1 |
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| Synonyms: | DNA topoisomerase I | DNA topoisomerase I (Topo I) | TOP1 | TOP1_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 90771.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11387 |
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| Residue: | 765 |
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| Sequence: | MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKEKDREKSKHSNSEHKDSEKK
HKEKEKTKHKDGSSEKHKDKHKDRDKEKRKEEKVRASGDAKIKKEKENGFSSPPQIKDEP
EDDGYFVPPKEDIKPLKRPRDEDDADYKPKKIKTEDTKKEKKRKLEEEEDGKLKKPKNKD
KDKKVPEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKF
YYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKC
DFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGL
FRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENI
QGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALY
FIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNK
VPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQ
QLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQTKIDAKKEQLAD
ARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSK
LNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF
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| BDBM50203046 |
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| n/a |
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| Name | BDBM50203046 |
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| Synonyms: | CHEMBL3913215 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H15IN2 |
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| Mol. Mass. | 422.2617 |
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| SMILES | [I-].C[n+]1ccc2cc(nc3-c4ccccc4-c1c23)-c1ccccc1 |
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| Structure | 
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