| Reaction Details |
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 | Report a problem with these data |
| Target | Orexin/Hypocretin receptor type 1 |
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| Ligand | BDBM50384416 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1625903 (CHEMBL3868372) |
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| Ki | 18±n/a nM |
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| Citation |  Stump, CA; Cooke, AJ; Bruno, J; Cabalu, TD; Gotter, AL; Harell, CM; Kuduk, SD; McDonald, TP; O'Brien, J; Renger, JJ; Williams, PD; Winrow, CJ; Coleman, PJ Discovery of highly potent and selective orexin 1 receptor antagonists (1-SORAs) suitable for in vivo interrogation of orexin 1 receptor pharmacology. Bioorg Med Chem Lett26:5809-5814 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Orexin/Hypocretin receptor type 1 |
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| Name: | Orexin/Hypocretin receptor type 1 |
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| Synonyms: | HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r |
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| Type: | Protein |
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| Mol. Mass.: | 47554.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O43613 |
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| Residue: | 425 |
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| Sequence: | MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
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| BDBM50384416 |
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| n/a |
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| Name | BDBM50384416 |
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| Synonyms: | CHEMBL2111553 | CHEMBL291536 | SB-334867 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H13N5O2 |
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| Mol. Mass. | 319.3174 |
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| SMILES | Cc1nc2ccc(NC(=O)Nc3ccnc4cccnc34)cc2o1 |
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| Structure | 
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