| Reaction Details |
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 | Report a problem with these data |
| Target | Orexin receptor type 2 |
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| Ligand | BDBM50203754 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1625855 (CHEMBL3868324) |
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| Ki | >10000±n/a nM |
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| Citation |  Stump, CA; Cooke, AJ; Bruno, J; Cabalu, TD; Gotter, AL; Harell, CM; Kuduk, SD; McDonald, TP; O'Brien, J; Renger, JJ; Williams, PD; Winrow, CJ; Coleman, PJ Discovery of highly potent and selective orexin 1 receptor antagonists (1-SORAs) suitable for in vivo interrogation of orexin 1 receptor pharmacology. Bioorg Med Chem Lett26:5809-5814 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Orexin receptor type 2 |
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| Name: | Orexin receptor type 2 |
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| Synonyms: | Hcrtr2 | Hypocretin receptor type 2 | OX2R_RAT | Orexin receptor 2 | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Ox-2-R | Ox2-R | Ox2R |
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| Type: | Protein |
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| Mol. Mass.: | 52508.46 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P56719 |
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| Residue: | 460 |
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| Sequence: | MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVS
CIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARR
KTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLS
EHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV
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| BDBM50203754 |
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| n/a |
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| Name | BDBM50203754 |
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| Synonyms: | CHEMBL3955752 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H18F2N4O2 |
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| Mol. Mass. | 408.4007 |
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| SMILES | FC1(F)CCN(C[C@@H]1Oc1ccc2ccccc2n1)C(=O)c1cccn2cncc12 |r| |
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| Structure | 
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