| Reaction Details |
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 | Report a problem with these data |
| Target | Sterol O-acyltransferase 1 |
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| Ligand | BDBM50204547 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1627618 (CHEMBL3870139) |
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| IC50 | 8900±n/a nM |
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| Citation |  Kobayashi, K; Ohshiro, T; Tomoda, H; Yin, F; Cui, HL; Chouthaiwale, PV; Tanaka, F Discovery of SOAT2 inhibitors from synthetic small molecules. Bioorg Med Chem Lett26:5899-5901 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sterol O-acyltransferase 1 |
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| Name: | Sterol O-acyltransferase 1 |
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| Synonyms: | ACAT-1 | ACAT1 | Acyl-coenzyme A:cholesterol acyltransferase 1 | Cholesterol acyltransferase 1 | SOAT1 | SOAT1_CHLAE | Sterol O-acyltransferase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 64744.47 |
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| Organism: | Chlorocebus aethiops |
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| Description: | ChEMBL_116975 |
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| Residue: | 550 |
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| Sequence: | MVGEEKMSLRNRLSKSRENPEEDEDQRKPAKESLEAPSNGRIDIKQLIAKKIKLTAEAEE
LKPFFMKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILEGEKNNHRAKDLRAPPEQGK
IFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGK
FPTVVWTWWIMFLSTFSVPYFLFQRWATGYSKSSHPLINSLFHGFLFMVFQIGILGFGPT
YVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYF
LFAPTLIYRDSYPRNPTVRWGYVAMQFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSAR
VLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTW
NVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFM
FFGMAFNFIVNDSRKKPIWNVMMWTSLFLGNGVLLCFYSQEWYARQHCPLKNPTFLDYVR
PRSWTCRYVF
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| BDBM50204547 |
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| n/a |
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| Name | BDBM50204547 |
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| Synonyms: | CHEMBL3923673 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24N2O3 |
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| Mol. Mass. | 364.4376 |
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| SMILES | CCC[C@@H]1CC(C[C@@]2(O1)C(=O)Nc1ccccc21)=NOCc1ccccc1 |r| |
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| Structure | 
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