| Reaction Details |
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 | Report a problem with these data |
| Target | Quinolone resistance protein NorA |
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| Ligand | BDBM50153287 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1636257 (CHEMBL3879155) |
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| IC50 | 17100±n/a nM |
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| Citation |  Buonerba, F; Lepri, S; Goracci, L; Schindler, BD; Seo, SM; Kaatz, GW; Cruciani, G Improved Potency of Indole-Based NorA Efflux Pump Inhibitors: From Serendipity toward Rational Design and Development. J Med Chem60:517-523 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Quinolone resistance protein NorA |
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| Name: | Quinolone resistance protein NorA |
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| Synonyms: | NORA_STAAU | norA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42273.03 |
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| Organism: | Staphylococcus aureus |
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| Description: | ChEMBL_961221 |
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| Residue: | 388 |
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| Sequence: | MNKQIFVLYFNIFLIFLGIGLVIPVLPVYLKDLGLTGSDLGLLVAAFALSQMIISPFGGT
LADKLGKKLIICIGLILFSVSEFMFAVGHNFSVLMLSRVIGGMSAGMVMPGVTGLIADIS
PSHQKAKNFGYMSAIINSGFILGPGIGGFMAEVSHRMPFYFAGALGILAFIMSIVLIHDP
KKSTTSGFQKLEPQLLTKINWKVFITPVILTLVLSFGLSAFETLYSLYTADKVNYSPKDI
SIAITGGGIFGALFQIYFFDKFMKYFSELTFIAWSLLYSVVVLILLVFANGYWSIMLISF
VVFIGFDMIRPAITNYFSNIAGERQGFAGGLNSTFTSMGNFIGPLIAGALFDVHIEAPIY
MAIGVSLAGVVIVLIEKQHRAKLKEQNM
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| BDBM50153287 |
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| n/a |
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| Name | BDBM50153287 |
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| Synonyms: | CHEMBL3775507 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H26N2O4 |
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| Mol. Mass. | 382.4528 |
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| SMILES | CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCC(O)CN)cc12 |
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| Structure | 
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