Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pirin (Homo sapiens (Human)) | BDBM50234078 (CHEMBL4087666 | US9701664, Example 63) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem | Article PubMed | 28 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of bisamide probe binding to pirin in human SKOV3 cells by SILAC-based quantitative mass spectrometry pull down assay | J Med Chem 60: 180-201 (2017) Article DOI: 10.1021/acs.jmedchem.6b01055 BindingDB Entry DOI: 10.7270/Q2KW5J9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pirin (Homo sapiens (Human)) | BDBM50234079 (CHEMBL4096048 | US9701664, Example 80) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of bisamide probe binding to pirin in human SKOV3 cells by SILAC-based quantitative mass spectrometry pull down assay | J Med Chem 60: 180-201 (2017) Article DOI: 10.1021/acs.jmedchem.6b01055 BindingDB Entry DOI: 10.7270/Q2KW5J9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin receptor type B (Homo sapiens (Human)) | BDBM50197953 (CHEMBL3980643) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Perugia Curated by ChEMBL | Assay Description Agonist activity at human recombinant ETB receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization by fluorimetric method | Eur J Med Chem 121: 658-670 (2016) Article DOI: 10.1016/j.ejmech.2016.06.006 BindingDB Entry DOI: 10.7270/Q2T155MF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin receptor type B (Homo sapiens (Human)) | BDBM50197955 (CHEMBL1515091) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.410 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Perugia Curated by ChEMBL | Assay Description Antagonist activity at ETB receptor in human BSMC assessed as inhibition of endothelin-1 or 3-mediated Ca2+ mobilization preincubated for 5 mins foll... | Eur J Med Chem 121: 658-670 (2016) Article DOI: 10.1016/j.ejmech.2016.06.006 BindingDB Entry DOI: 10.7270/Q2T155MF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50197954 (CHEBI:2965 | CHEMBL314691) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.620 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Perugia Curated by ChEMBL | Assay Description Antagonist activity at ETA receptor in human SKNMC cells assessed as inhibition of endothelin-1-mediated Ca2+ mobilization by fura-2/AM dye-based spe... | Eur J Med Chem 121: 658-670 (2016) Article DOI: 10.1016/j.ejmech.2016.06.006 BindingDB Entry DOI: 10.7270/Q2T155MF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50197953 (CHEMBL3980643) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.670 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Perugia Curated by ChEMBL | Assay Description Agonist activity at ETA receptor in human SKNMC cells assessed as induction of Ca2+ mobilization by fluorimetric method | Eur J Med Chem 121: 658-670 (2016) Article DOI: 10.1016/j.ejmech.2016.06.006 BindingDB Entry DOI: 10.7270/Q2T155MF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock factor protein 1 (Homo sapiens (Human)) | BDBM50234074 (CHEMBL4070633 | US9701664, Example 39) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of 17-AAG-induced HSF1 pathway in human U20S cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addit... | J Med Chem 60: 180-201 (2017) Article DOI: 10.1021/acs.jmedchem.6b01055 BindingDB Entry DOI: 10.7270/Q2KW5J9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock factor protein 1 (Homo sapiens (Human)) | BDBM50234074 (CHEMBL4070633 | US9701664, Example 39) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of 17-AAG-induced HSF1 pathway in human U20S cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addit... | J Med Chem 60: 180-201 (2017) Article DOI: 10.1021/acs.jmedchem.6b01055 BindingDB Entry DOI: 10.7270/Q2KW5J9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50061101 (4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Perugia Curated by ChEMBL | Assay Description Binding affinity to human ETA receptor | Eur J Med Chem 121: 658-670 (2016) Article DOI: 10.1016/j.ejmech.2016.06.006 BindingDB Entry DOI: 10.7270/Q2T155MF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock factor protein 1 (Homo sapiens (Human)) | BDBM50234073 (CHEMBL4063330 | US9701664, Example 1) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi... | J Med Chem 60: 180-201 (2017) Article DOI: 10.1021/acs.jmedchem.6b01055 BindingDB Entry DOI: 10.7270/Q2KW5J9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock factor protein 1 (Homo sapiens (Human)) | BDBM50234073 (CHEMBL4063330 | US9701664, Example 1) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi... | J Med Chem 60: 180-201 (2017) Article DOI: 10.1021/acs.jmedchem.6b01055 BindingDB Entry DOI: 10.7270/Q2KW5J9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock factor protein 1 (Homo sapiens (Human)) | BDBM50234078 (CHEMBL4087666 | US9701664, Example 63) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi... | J Med Chem 60: 180-201 (2017) Article DOI: 10.1021/acs.jmedchem.6b01055 BindingDB Entry DOI: 10.7270/Q2KW5J9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock factor protein 1 (Homo sapiens (Human)) | BDBM50234078 (CHEMBL4087666 | US9701664, Example 63) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi... | J Med Chem 60: 180-201 (2017) Article DOI: 10.1021/acs.jmedchem.6b01055 BindingDB Entry DOI: 10.7270/Q2KW5J9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock factor protein 1 (Homo sapiens (Human)) | BDBM50234085 (CHEMBL4102297 | US9701664, Example 89) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi... | J Med Chem 60: 180-201 (2017) Article DOI: 10.1021/acs.jmedchem.6b01055 BindingDB Entry DOI: 10.7270/Q2KW5J9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock factor protein 1 (Homo sapiens (Human)) | BDBM50234085 (CHEMBL4102297 | US9701664, Example 89) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi... | J Med Chem 60: 180-201 (2017) Article DOI: 10.1021/acs.jmedchem.6b01055 BindingDB Entry DOI: 10.7270/Q2KW5J9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock factor protein 1 (Homo sapiens (Human)) | BDBM50234078 (CHEMBL4087666 | US9701664, Example 63) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSPA1A mRNA level preincubated for 1 hr followed by 17-AAG ad... | J Med Chem 60: 180-201 (2017) Article DOI: 10.1021/acs.jmedchem.6b01055 BindingDB Entry DOI: 10.7270/Q2KW5J9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock factor protein 1 (Homo sapiens (Human)) | BDBM50234078 (CHEMBL4087666 | US9701664, Example 63) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSPA1A mRNA level preincubated for 1 hr followed by 17-AAG ad... | J Med Chem 60: 180-201 (2017) Article DOI: 10.1021/acs.jmedchem.6b01055 BindingDB Entry DOI: 10.7270/Q2KW5J9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock factor protein 1 (Homo sapiens (Human)) | BDBM50234090 (CHEMBL4069552 | US9701664, Example 2) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi... | J Med Chem 60: 180-201 (2017) Article DOI: 10.1021/acs.jmedchem.6b01055 BindingDB Entry DOI: 10.7270/Q2KW5J9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock factor protein 1 (Homo sapiens (Human)) | BDBM50234090 (CHEMBL4069552 | US9701664, Example 2) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi... | J Med Chem 60: 180-201 (2017) Article DOI: 10.1021/acs.jmedchem.6b01055 BindingDB Entry DOI: 10.7270/Q2KW5J9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock factor protein 1 (Homo sapiens (Human)) | BDBM50234074 (CHEMBL4070633 | US9701664, Example 39) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi... | J Med Chem 60: 180-201 (2017) Article DOI: 10.1021/acs.jmedchem.6b01055 BindingDB Entry DOI: 10.7270/Q2KW5J9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock factor protein 1 (Homo sapiens (Human)) | BDBM50234074 (CHEMBL4070633 | US9701664, Example 39) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi... | J Med Chem 60: 180-201 (2017) Article DOI: 10.1021/acs.jmedchem.6b01055 BindingDB Entry DOI: 10.7270/Q2KW5J9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50197957 (CHEMBL3891334) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Perugia Curated by ChEMBL | Assay Description Agonist activity at ETA receptor in human SKNMC cells assessed as induction of Ca2+ mobilization by fluorimetric method | Eur J Med Chem 121: 658-670 (2016) Article DOI: 10.1016/j.ejmech.2016.06.006 BindingDB Entry DOI: 10.7270/Q2T155MF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin receptor type B (Homo sapiens (Human)) | BDBM50061101 (4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 95 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Perugia Curated by ChEMBL | Assay Description Binding affinity to human ETB receptor | Eur J Med Chem 121: 658-670 (2016) Article DOI: 10.1016/j.ejmech.2016.06.006 BindingDB Entry DOI: 10.7270/Q2T155MF | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Heat shock factor protein 1 (Homo sapiens (Human)) | BDBM50234083 (CHEMBL4070302 | US9701664, Example 81) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 115 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi... | J Med Chem 60: 180-201 (2017) Article DOI: 10.1021/acs.jmedchem.6b01055 BindingDB Entry DOI: 10.7270/Q2KW5J9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock factor protein 1 (Homo sapiens (Human)) | BDBM50234083 (CHEMBL4070302 | US9701664, Example 81) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi... | J Med Chem 60: 180-201 (2017) Article DOI: 10.1021/acs.jmedchem.6b01055 BindingDB Entry DOI: 10.7270/Q2KW5J9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock factor protein 1 (Homo sapiens (Human)) | BDBM50234079 (CHEMBL4096048 | US9701664, Example 80) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi... | J Med Chem 60: 180-201 (2017) Article DOI: 10.1021/acs.jmedchem.6b01055 BindingDB Entry DOI: 10.7270/Q2KW5J9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock factor protein 1 (Homo sapiens (Human)) | BDBM50234079 (CHEMBL4096048 | US9701664, Example 80) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 224 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi... | J Med Chem 60: 180-201 (2017) Article DOI: 10.1021/acs.jmedchem.6b01055 BindingDB Entry DOI: 10.7270/Q2KW5J9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase B-raf (Homo sapiens (Human)) | BDBM50234074 (CHEMBL4070633 | US9701664, Example 39) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 417 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of full length human recombinant GST-tagged BRAF (S429 to E741 residues) expressed in baculovirus expression system using Ser/Thr 03 mixtu... | J Med Chem 60: 180-201 (2017) Article DOI: 10.1021/acs.jmedchem.6b01055 BindingDB Entry DOI: 10.7270/Q2KW5J9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase B-raf (Homo sapiens (Human)) | BDBM50234074 (CHEMBL4070633 | US9701664, Example 39) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of full length human recombinant GST-tagged BRAF (S429 to E741 residues) expressed in baculovirus expression system using Ser/Thr 03 mixtu... | J Med Chem 60: 180-201 (2017) Article DOI: 10.1021/acs.jmedchem.6b01055 BindingDB Entry DOI: 10.7270/Q2KW5J9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock factor protein 1 (Homo sapiens (Human)) | BDBM50234076 (CHEMBL4077078) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 447 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi... | J Med Chem 60: 180-201 (2017) Article DOI: 10.1021/acs.jmedchem.6b01055 BindingDB Entry DOI: 10.7270/Q2KW5J9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock factor protein 1 (Homo sapiens (Human)) | BDBM50234076 (CHEMBL4077078) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi... | J Med Chem 60: 180-201 (2017) Article DOI: 10.1021/acs.jmedchem.6b01055 BindingDB Entry DOI: 10.7270/Q2KW5J9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Quinolone resistance protein NorA (Staphylococcus aureus) | BDBM50211232 (CHEMBL3929187) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Perugia Curated by ChEMBL | Assay Description Inhibition of Staphylococcus aureus 1199B NorA assessed as inhibition of ethidium bromide efflux measured after 5 mins by fluorometric method | J Med Chem 60: 517-523 (2017) Article DOI: 10.1021/acs.jmedchem.6b01281 BindingDB Entry DOI: 10.7270/Q2D79DKR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Quinolone resistance protein NorA (Staphylococcus aureus) | BDBM50211228 (CHEMBL3956740) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.02E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Perugia Curated by ChEMBL | Assay Description Inhibition of Staphylococcus aureus 1199B NorA assessed as inhibition of ethidium bromide efflux measured after 5 mins by fluorometric method | J Med Chem 60: 517-523 (2017) Article DOI: 10.1021/acs.jmedchem.6b01281 BindingDB Entry DOI: 10.7270/Q2D79DKR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock factor protein 1 (Homo sapiens (Human)) | BDBM50234072 (CHEMBL4099031) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.57E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi... | J Med Chem 60: 180-201 (2017) Article DOI: 10.1021/acs.jmedchem.6b01055 BindingDB Entry DOI: 10.7270/Q2KW5J9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock factor protein 1 (Homo sapiens (Human)) | BDBM50234072 (CHEMBL4099031) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi... | J Med Chem 60: 180-201 (2017) Article DOI: 10.1021/acs.jmedchem.6b01055 BindingDB Entry DOI: 10.7270/Q2KW5J9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Quinolone resistance protein NorA (Staphylococcus aureus) | BDBM50211230 (CHEMBL3948087) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.83E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Perugia Curated by ChEMBL | Assay Description Inhibition of Staphylococcus aureus 1199B NorA assessed as inhibition of ethidium bromide efflux measured after 5 mins by fluorometric method | J Med Chem 60: 517-523 (2017) Article DOI: 10.1021/acs.jmedchem.6b01281 BindingDB Entry DOI: 10.7270/Q2D79DKR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Quinolone resistance protein NorA (Staphylococcus aureus) | BDBM50153269 (CHEMBL3775575) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Perugia Curated by ChEMBL | Assay Description Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-... | J Med Chem 59: 867-91 (2016) Article DOI: 10.1021/acs.jmedchem.5b01219 BindingDB Entry DOI: 10.7270/Q28W3G57 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Quinolone resistance protein NorA (Staphylococcus aureus) | BDBM50153316 (CHEMBL3775207) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Perugia Curated by ChEMBL | Assay Description Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-... | J Med Chem 59: 867-91 (2016) Article DOI: 10.1021/acs.jmedchem.5b01219 BindingDB Entry DOI: 10.7270/Q28W3G57 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Quinolone resistance protein NorA (Staphylococcus aureus) | BDBM50153186 (CHEMBL3774520) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Perugia Curated by ChEMBL | Assay Description Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-... | J Med Chem 59: 867-91 (2016) Article DOI: 10.1021/acs.jmedchem.5b01219 BindingDB Entry DOI: 10.7270/Q28W3G57 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Quinolone resistance protein NorA (Staphylococcus aureus) | BDBM50211229 (CHEMBL3955315) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.93E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Perugia Curated by ChEMBL | Assay Description Inhibition of Staphylococcus aureus 1199B NorA assessed as inhibition of ethidium bromide efflux measured after 5 mins by fluorometric method | J Med Chem 60: 517-523 (2017) Article DOI: 10.1021/acs.jmedchem.6b01281 BindingDB Entry DOI: 10.7270/Q2D79DKR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Quinolone resistance protein NorA (Staphylococcus aureus) | BDBM50153183 (CHEMBL3774548) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Perugia Curated by ChEMBL | Assay Description Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-... | J Med Chem 59: 867-91 (2016) Article DOI: 10.1021/acs.jmedchem.5b01219 BindingDB Entry DOI: 10.7270/Q28W3G57 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Quinolone resistance protein NorA (Staphylococcus aureus) | BDBM50153314 (CHEMBL3774689) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Perugia Curated by ChEMBL | Assay Description Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-... | J Med Chem 59: 867-91 (2016) Article DOI: 10.1021/acs.jmedchem.5b01219 BindingDB Entry DOI: 10.7270/Q28W3G57 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Quinolone resistance protein NorA (Staphylococcus aureus) | BDBM50153284 (CHEMBL3775852) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Perugia Curated by ChEMBL | Assay Description Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-... | J Med Chem 59: 867-91 (2016) Article DOI: 10.1021/acs.jmedchem.5b01219 BindingDB Entry DOI: 10.7270/Q28W3G57 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Quinolone resistance protein NorA (Staphylococcus aureus) | BDBM50153278 (CHEMBL3775105) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Perugia Curated by ChEMBL | Assay Description Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-... | J Med Chem 59: 867-91 (2016) Article DOI: 10.1021/acs.jmedchem.5b01219 BindingDB Entry DOI: 10.7270/Q28W3G57 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Quinolone resistance protein NorA (Staphylococcus aureus) | BDBM50153278 (CHEMBL3775105) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Perugia Curated by ChEMBL | Assay Description Inhibition of Staphylococcus aureus 1199B NorA assessed as inhibition of ethidium bromide efflux measured after 5 mins by fluorometric method | J Med Chem 60: 517-523 (2017) Article DOI: 10.1021/acs.jmedchem.6b01281 BindingDB Entry DOI: 10.7270/Q2D79DKR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Quinolone resistance protein NorA (Staphylococcus aureus) | BDBM50153317 (CHEMBL3774886) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Perugia Curated by ChEMBL | Assay Description Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-... | J Med Chem 59: 867-91 (2016) Article DOI: 10.1021/acs.jmedchem.5b01219 BindingDB Entry DOI: 10.7270/Q28W3G57 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Quinolone resistance protein NorA (Staphylococcus aureus) | BDBM50153271 (CHEMBL3774968) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 6.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Perugia Curated by ChEMBL | Assay Description Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-... | J Med Chem 59: 867-91 (2016) Article DOI: 10.1021/acs.jmedchem.5b01219 BindingDB Entry DOI: 10.7270/Q28W3G57 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Quinolone resistance protein NorA (Staphylococcus aureus) | BDBM50153187 (CHEMBL3775401) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Perugia Curated by ChEMBL | Assay Description Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-... | J Med Chem 59: 867-91 (2016) Article DOI: 10.1021/acs.jmedchem.5b01219 BindingDB Entry DOI: 10.7270/Q28W3G57 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Quinolone resistance protein NorA (Staphylococcus aureus) | BDBM50153268 (CHEMBL3775173) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Perugia Curated by ChEMBL | Assay Description Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-... | J Med Chem 59: 867-91 (2016) Article DOI: 10.1021/acs.jmedchem.5b01219 BindingDB Entry DOI: 10.7270/Q28W3G57 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Quinolone resistance protein NorA (Staphylococcus aureus) | BDBM50153270 (CHEMBL3775819) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Perugia Curated by ChEMBL | Assay Description Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-... | J Med Chem 59: 867-91 (2016) Article DOI: 10.1021/acs.jmedchem.5b01219 BindingDB Entry DOI: 10.7270/Q28W3G57 | |||||||||||
More data for this Ligand-Target Pair |
Displayed 1 to 50 (of 132 total ) | Next | Last >> |