Reaction Details |
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Target | Pirin |
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Ligand | BDBM50234078 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1652047 (CHEMBL4001302) |
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Ki | 28±n/a nM |
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Citation | Cheeseman, MD; Chessum, NE; Rye, CS; Pasqua, AE; Tucker, MJ; Wilding, B; Evans, LE; Lepri, S; Richards, M; Sharp, SY; Ali, S; Rowlands, M; O'Fee, L; Miah, A; Hayes, A; Henley, AT; Powers, M; Te Poele, R; De Billy, E; Pellegrino, L; Raynaud, F; Burke, R; van Montfort, RL; Eccles, SA; Workman, P; Jones, K Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen. J Med Chem60:180-201 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Pirin |
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Name: | Pirin |
Synonyms: | PIR | PIR_HUMAN | Probable quercetin 2,3-dioxygenase PIR | Probable quercetinase |
Type: | PROTEIN |
Mol. Mass.: | 32115.50 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_811273 |
Residue: | 290 |
Sequence: | MGSSKKVTLSVLSREQSEGVGARVRRSIGRPELKNLDPFLLFDEFKGGRPGGFPDHPHRG
FETVSYLLEGGSMAHEDFCGHTGKMNPGDLQWMTAGRGILHAEMPCSEEPAHGLQLWVNL
RSSEKMVEPQYQELKSEEIPKPSKDGVTVAVISGEALGIKSKVYTRTPTLYLDFKLDPGA
KHSQPIPKGWTSFIYTISGDVYIGPDDAQQKIEPHHTAVLGEGDSVQVENKDPKRSHFVL
IAGEPLREPVIQHGPFVMNTNEEISQAILDFRNAKNGFERAKTWKSKIGN
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BDBM50234078 |
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n/a |
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Name | BDBM50234078 |
Synonyms: | CHEMBL4087666 | US9701664, Example 63 |
Type | Small organic molecule |
Emp. Form. | C32H32N4O5 |
Mol. Mass. | 552.6203 |
SMILES | Cc1ccc(NC(=O)c2ccc3OCCOc3c2)cc1NC(=O)c1ccc2nc(OCCN3CCCC3)ccc2c1 |
Structure |
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