Reaction Details |
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Target | Diacylglycerol lipase-alpha |
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Ligand | BDBM50211262 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_1636271 |
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IC50 | 79±n/a nM |
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Citation | Deng, H; Kooijman, S; van den Nieuwendijk, AM; Ogasawara, D; van der Wel, T; van Dalen, F; Baggelaar, MP; Janssen, FJ; van den Berg, RJ; den Dulk, H; Cravatt, BF; Overkleeft, HS; Rensen, PC; van der Stelt, M Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding. J Med Chem60:428-440 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Diacylglycerol lipase-alpha |
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Name: | Diacylglycerol lipase-alpha |
Synonyms: | DGL-alpha | DGLA_MOUSE | Dagla | Kiaa0659 | Neural stem cell-derived dendrite regulator | Nsddr | Sn1-specific diacylglycerol lipase alpha |
Type: | PROTEIN |
Mol. Mass.: | 115371.22 |
Organism: | Mus musculus |
Description: | ChEMBL_101098 |
Residue: | 1044 |
Sequence: | MPGIVVFRRRWSVGSDDLVLPAIFLFLLHTTWFVILSVVLFGLVYNPHEACSLNLVDHGR
GYLGILLSCMIAEMAIIWLSMRGGILYTEPRDSMQYVLYVRLAILVIEFIYAIVGIVWLT
QYYTSCNDLTAKNVTLGMVVCNWVVILSVCITVLCVFDPTGRTFVKLRATKRRQRNLRTY
NLRHRLEEGQATSWSRRLKVFLCCTRTKDSQSDAYSEIAYLFAEFFRDLDIVPSDIIAGL
VLLRQRQRAKRNAVLDEANNDILAFLSGMPVTRNTKYLDLKNSHEMLRYKEVCYYMLFAL
AAYGWPMYLMRKPTCGLCQLARSCSCCLCPARPRFAPGVTIEEDNCCGCNAIAIRRHFLD
ENMTAVDIVYTSCHDAVYETPFYVAVDHDKKKVVISIRGTLSPKDALTDLTGDAERLPVE
GHRGTWLGHKGMVLSAEYIKKKLEQEMVLSQAFGRDLGRGTKHYGLIVVGHSLGAGTAAI
LSFLLRPQYPTLKCFAYSPPGGLLSEDAMEYSKEFVTAVVLGKDLVPRIGLSQLEGFRRQ
LLDVLQRSTKPKWRIIVGATKCIPKSELPEDQVEVTTLASTRLWTHPSDLTIALSASTPL
YPPGRIIHVVHNHPAEQCCCCEQEEPTYFAIWGDNKAFNEVIISPAMLHEHLPYVVMEGL
NKVLENYNKGKTALLSAAKVMVSPTEVDLTPELIFQQQPLPTGPPLPTGLALELPATEHR
NSSVRSKSQSEMSLEGFSEGRLLSPVAAASAARQDPVELLLLSTQERLAAELQSRRAPLA
TMESLSDTESLYSFDSRRSSGFRSIRGSPSLHAVLERDEGHLFYIDPAIPEENPSLSSRT
ELLAADSLSKHSQDTQPLEAALGSGGVTPERPPSATIEEEEAAGGSEGGGVAPRGELALH
NGRLGDSPSPQVLEFAEFIDSLFNLDSKSSSFQDLYCMMVPESPTSDYTEGPKSPSQQEI
LLRAQFEPNLVPKPPRLFAGSAEPSSGISLSPSFPLSSSGELMDLTPTGLSSQECLATDK
IRTSTPTGHGASPTKQDDLVISAR
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BDBM50211262 |
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n/a |
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Name | BDBM50211262 |
Synonyms: | CHEMBL3922787 |
Type | Small organic molecule |
Emp. Form. | C29H28F2N4O3 |
Mol. Mass. | 518.5544 |
SMILES | CO[C@H]1CC[C@H](Cc2ccccc2)N(C1)C(=O)n1ncc(n1)C(O)(c1ccc(F)cc1)c1ccc(F)cc1 |r| |
Structure |
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