| Reaction Details |
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 | Report a problem with these data |
| Target | Diacylglycerol lipase-beta |
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| Ligand | BDBM50211235 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1636262 |
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| IC50 | 79±n/a nM |
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| Citation |  Deng, H; Kooijman, S; van den Nieuwendijk, AM; Ogasawara, D; van der Wel, T; van Dalen, F; Baggelaar, MP; Janssen, FJ; van den Berg, RJ; den Dulk, H; Cravatt, BF; Overkleeft, HS; Rensen, PC; van der Stelt, M Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding. J Med Chem60:428-440 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Diacylglycerol lipase-beta |
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| Name: | Diacylglycerol lipase-beta |
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| Synonyms: | DGL-beta | DGLB_MOUSE | Daglb | Sn1-specific diacylglycerol lipase beta |
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| Type: | PROTEIN |
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| Mol. Mass.: | 73906.34 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_101275 |
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| Residue: | 669 |
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| Sequence: | MPGMVLFGRRWSLASDDLVFPGSFELFLRVLWWIVSLTLYLTHRRRLDCPGGVLLSTYLI
VLLVLLAVIICTVLAIVCVSMRGTICNPGPRKSMSKLLYIRLALFLPEMVWASLGAAWVA
KGIQCDRTVVIGIIATVIVSWIVIAATMVTIIFVFDPLGGKMAPYPPCIPEHLDSNSSNR
LLTGLKTAAKSVWETRVQFCCCCVGQDDNTRVAFSSTADLFSTYFSDTDLVPSDIAAGFT
LLHQQQDNISHSREPPEVVTHTPGQPQETELDAEVENCHHYMPFAAAAYGWPLYIYRNPF
TGLCRIGGDCCRARDIEYDAVEGDQHNCHFASILKTTGLQYRDFIHISFHDKVYELPFIV
VLDHRKESVVVAVRGTMSLQDVLTDLSAESETLELGIELQDCVAHKGIAQAARYIHRRLV
NDGILSQAFSVAPEYQLVLVGHSLGAGAAALLAIMLRGAYPQVRAYAFSPPRGLLSKSLY
EYSKDFVVSLILGMDVIPRLSVTNMEDLKRRILRVIANCNKPKYKILLHGCWYGLFGGSP
DNFPTELDEGTQGALTQPLLGEQTLLTRYSPGYCSSDSPLDSPTKYPTLYPPGRIIHLEE
EGGSGRFGCCSAAQYRARWAHEAEFSKILIGPKMLIDHMPDVMIRALDRVLADRTACVSC
PGQGGSSVP
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| BDBM50211235 |
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| n/a |
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| Name | BDBM50211235 |
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| Synonyms: | CHEMBL3974512 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H28N4O2 |
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| Mol. Mass. | 452.5475 |
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| SMILES | OC(c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1)(c1ccccc1)c1ccccc1 |
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| Structure | 
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