| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Lanosterol 14-alpha demethylase |
|---|
| Ligand | BDBM50215879 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_151527 (CHEMBL762240) |
|---|
| IC50 | 56.3±n/a nM |
|---|
| Citation |  Tsukuda, T; Shiratori, Y; Watanabe, M; Ontsuka, H; Hattori, K; Shirai, M; Shimma, N Modeling, synthesis and biological activity of novel antifungal agents (1). Bioorg Med Chem Lett8:1819-24 (1998) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Lanosterol 14-alpha demethylase |
|---|
| Name: | Lanosterol 14-alpha demethylase |
|---|
| Synonyms: | CP51A_HUMAN | CYP51 | CYP51A1 | CYPLI | Cytochrome P450 51 | Cytochrome P450 51A1 | LDM | Lanosterol 14-alpha demethylase | P450-14DM | P45014DM | P450LI | Sterol 14α-demethylase (CYP51) | Sterol 14-alpha demethylase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 56817.21 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q16850 |
|---|
| Residue: | 509 |
|---|
| Sequence: | MAAAAGMLLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQL
PAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAA
ALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSI
IEKETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGF
SHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGR
PLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTY
DQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDS
WVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDL
IDGYFPTVNYTTMIHTPENPVIRYKRRSK
|
|
|
|---|
| BDBM50215879 |
|---|
| n/a |
|---|
| Name | BDBM50215879 |
|---|
| Synonyms: | CHEMBL415943 | Ro-092435 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H25F3N4O3 |
|---|
| Mol. Mass. | 426.4327 |
|---|
| SMILES | CO\N=C1/[C@@H](Cn2cncn2)[C@H](COc2ccc(OC(F)(F)F)cc2)CCC1(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
