| Reaction Details |
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 | Report a problem with these data |
| Target | Lanosterol 14-alpha demethylase |
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| Ligand | BDBM50215881 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_151527 (CHEMBL762240) |
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| IC50 | 130±n/a nM |
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| Citation |  Tsukuda, T; Shiratori, Y; Watanabe, M; Ontsuka, H; Hattori, K; Shirai, M; Shimma, N Modeling, synthesis and biological activity of novel antifungal agents (1). Bioorg Med Chem Lett8:1819-24 (1998) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Lanosterol 14-alpha demethylase |
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| Name: | Lanosterol 14-alpha demethylase |
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| Synonyms: | CP51A_HUMAN | CYP51 | CYP51A1 | CYPLI | Cytochrome P450 51 | Cytochrome P450 51A1 | LDM | Lanosterol 14-alpha demethylase | P450-14DM | P45014DM | P450LI | Sterol 14α-demethylase (CYP51) | Sterol 14-alpha demethylase |
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| Type: | Protein |
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| Mol. Mass.: | 56817.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16850 |
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| Residue: | 509 |
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| Sequence: | MAAAAGMLLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQL
PAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAA
ALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSI
IEKETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGF
SHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGR
PLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTY
DQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDS
WVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDL
IDGYFPTVNYTTMIHTPENPVIRYKRRSK
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| BDBM50215881 |
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| n/a |
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| Name | BDBM50215881 |
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| Synonyms: | CHEMBL415955 | Ro-092385 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H23F3N4O3 |
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| Mol. Mass. | 412.4061 |
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| SMILES | CC1(C)CC[C@@H](COc2ccc(OC(F)(F)F)cc2)[C@H](Cn2cncn2)\C1=N/O |
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| Structure | 
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