| Reaction Details |
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 | Report a problem with these data |
| Target | Sporulation kinase A |
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| Ligand | BDBM50215967 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_87376 (CHEMBL694305) |
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| IC50 | 4800±n/a nM |
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| Citation |  Hlasta, DJ; Demers, JP; Foleno, BD; Fraga-Spano, SA; Guan, J; Hilliard, JJ; Macielag, MJ; Ohemeng, KA; Sheppard, CM; Sui, Z; Webb, GC; Weidner-Wells, MA; Werblood, H; Barrett, JF Novel inhibitors of bacterial two-component systems with gram positive antibacterial activity: pharmacophore identification based on the screening hit closantel. Bioorg Med Chem Lett8:1923-8 (1998) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Sporulation kinase A |
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| Name: | Sporulation kinase A |
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| Synonyms: | KINA_BACSU | Sporulation kinase A | Stage II sporulation protein F | Stage II sporulation protein J | gsiC | kinA | scoD | spoIIF | spoIIJ |
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| Type: | PROTEIN |
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| Mol. Mass.: | 69161.05 |
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| Organism: | Bacillus subtilis (strain 168) |
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| Description: | ChEMBL_105028 |
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| Residue: | 606 |
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| Sequence: | MEQDTQHVKPLQTKTDIHAVLASNGRIIYISANSKLHLGYLQGEMIGSFLKTFLHEEDQF
LVESYFYNEHHLMPCTFRFIKKDHTIVWVEAAVEIVTTRAERTEREIILKMKVLEEETGH
QSLNCEKHEIEPASPESTTYITDDYERLVENLPSPLCISVKGKIVYVNSAMLSMLGAKSK
DAIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQTWKRLDGTPVHLEVKASPTVYK
NQQAELLLLIDISSRKKFQTILQKSRERYQLLIQNSIDTIAVIHNGKWVFMNESGISLFE
AATYEDLIGKNIYDQLHPCDHEDVKERIQNIAEQKTESEIVKQSWFTFQNRVIYTEMVCI
PTTFFGEAAVQVILRDISERKQTEELMLKSEKLSIAGQLAAGIAHEIRNPLTAIKGFLQL
MKPTMEGNEHYFDIVFSELSRIELILSELLMLAKPQQNAVKEYLNLKKLIGEVSALLETQ
ANLNGIFIRTSYEKDSIYINGDQNQLKQVFINLIKNAVESMPDGGTVDIIITEDEHSVHV
TVKDEGEGIPEKVLNRIGEPFLTTKEKGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFK
ISFPKK
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| BDBM50215967 |
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| n/a |
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| Name | BDBM50215967 |
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| Synonyms: | CHEMBL56579 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H14Cl4N2O2 |
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| Mol. Mass. | 480.171 |
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| SMILES | Cc1cc(NC(=O)c2cc(Cl)cc(Cl)c2O)c(Cl)cc1C(C#N)c1ccc(Cl)cc1 |
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| Structure | 
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