| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glycylpeptide N-tetradecanoyltransferase 1/2 |
|---|
| Ligand | BDBM96235 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_141169 (CHEMBL750519) |
|---|
| IC50 | 980±n/a nM |
|---|
| Citation |  Masubuchi, M; Kawasaki, K; Ebiike, H; Ikeda, Y; Tsujii, S; Sogabe, S; Fujii, T; Sakata, K; Shiratori, Y; Aoki, Y; Ohtsuka, T; Shimma, N Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 1. Bioorg Med Chem Lett11:1833-7 (2001) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glycylpeptide N-tetradecanoyltransferase 1/2 |
|---|
| Name: | Glycylpeptide N-tetradecanoyltransferase 1/2 |
|---|
| Synonyms: | Peptide N-myristoyltransferase |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of ChEMBL is 141178 |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Glycylpeptide N-tetradecanoyltransferase 2 |
|---|
| Synonyms: | Glycylpeptide N-tetradecanoyltransferase 2 | Myristoyl-CoA:protein N-myristoyltransferase 2 | NMT 2 | NMT2 | NMT2_HUMAN | Peptide N-myristoyltransferase 2 | Type II N-myristoyltransferase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 56986.61 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1435042 |
|---|
| Residue: | 498 |
|---|
| Sequence: | MAEDSESAASQQSLELDDQDTCGIDGDNEEETEHAKGSPGGYLGAKKKKKKQKRKKEKPN
SGGTKSDSASDSQEIKIQQPSKNPSVPMQKLQDIQRAMELLSACQGPARNIDEAAKHRYQ
FWDTQPVPKLDEVITSHGAIEPDKDNVRQEPYSLPQGFMWDTLDLSDAEVLKELYTLLNE
NYVEDDDNMFRFDYSPEFLLWALRPPGWLLQWHCGVRVSSNKKLVGFISAIPANIRIYDS
VKKMVEINFLCVHKKLRSKRVAPVLIREITRRVNLEGIFQAVYTAGVVLPKPIATCRYWH
RSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPDVTKTSGLRPMEPKDIKSVRELINTYLK
QFHLAPVMDEEEVAHWFLPREHIIDTFVVESPNGKLTDFLSFYTLPSTVMHHPAHKSLKA
AYSFYNIHTETPLLDLMSDALILAKSKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYL
YNWRCPGTDSEKVGLVLQ
|
|
|
|---|
| Component 2 |
| Name: | Glycylpeptide N-tetradecanoyltransferase 1 |
|---|
| Synonyms: | Myristoyl-CoA:protein N-myristoyltransferase (Nmt) | N-myristoyltransferase (NMT1) | NMT | NMT1 | NMT1_HUMAN | Peptide N-myristoyltransferase | Peptide N-myristoyltransferase 1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 56814.10 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P30419 |
|---|
| Residue: | 496 |
|---|
| Sequence: | MADESETAVKPPAPPLPQMMEGNGNGHEHCSDCENEEDNSYNRGGLSPANDTGAKKKKKK
QKKKKEKGSETDSAQDQPVKMNSLPAERIQEIQKAIELFSVGQGPAKTMEEASKRSYQFW
DTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDALDLGDRGVLKELYTLLNENY
VEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEK
KMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRS
LNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLLTRYLKQF
HLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAY
SFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYN
WKCPSMGAEKVGLVLQ
|
|
|
|---|
| BDBM96235 |
|---|
| n/a |
|---|
| Name | BDBM96235 |
|---|
| Synonyms: | 4-[2-hydroxy-3-(isopropylamino)propoxy]-3-methyl-coumarilic acid ethyl ester;hydrochloride | 4-[2-hydroxy-3-(propan-2-ylamino)propoxy]-3-methyl-2-benzofurancarboxylic acid ethyl ester;hydrochloride | CHEMBL53849 | MLS000039218 | Non peptidic, 1 | SMR000036354 | cid_6602742 | ethyl 3-methyl-4-[2-oxidanyl-3-(propan-2-ylamino)propoxy]-1-benzofuran-2-carboxylate;hydrochloride | ethyl 4-[2-hydroxy-3-(propan-2-ylamino)propoxy]-3-methyl-1-benzofuran-2-carboxylate;hydrochloride |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H25NO5 |
|---|
| Mol. Mass. | 335.3948 |
|---|
| SMILES | CCOC(=O)c1oc2cccc(OCC(O)CNC(C)C)c2c1C |
|---|
| Structure | 
|
|---|
Search and Browse
