Reaction Details | |||
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Target | Mitogen-activated protein kinase 11/12/13/14 | ||
Ligand | BDBM50219251 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_221159 (CHEMBL842194) | ||
IC50 | 16±n/a nM | ||
Citation | Collis, AJ; Foster, ML; Halley, F; Maslen, C; McLay, IM; Page, KM; Redford, EJ; Souness, JE; Wilsher, NE RPR203494 a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency. Bioorg Med Chem Lett11:693-6 (2001) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
Mitogen-activated protein kinase 11/12/13/14 | |||
Name: | Mitogen-activated protein kinase 11/12/13/14 | ||
Synonyms: | MAP kinase p38 | ||
Type: | n/a | ||
Mol. Mass.: | n/a | ||
Description: | ASSAY_ID of ChEMBL is 221159 | ||
Components: | This complex has 4 components. | ||
Component 1 | |||
Name: | Mitogen-activated protein kinase 12 | ||
Synonyms: | ERK-6 | Extracellular signal-regulated kinase 6 | MAP kinase 12 | MAP kinase p38 gamma | MAPK 12 | MK12_MOUSE | Mapk12 | Mitogen-activated protein kinase 12 | Mitogen-activated protein kinase p38 gamma | Sapk3 | Stress-activated protein kinase 3 | ||
Type: | PROTEIN | ||
Mol. Mass.: | 42041.30 | ||
Organism: | Mus musculus | ||
Description: | ChEMBL_105000 | ||
Residue: | 367 | ||
Sequence: |
| ||
Component 2 | |||
Name: | Mitogen-activated protein kinase 11 | ||
Synonyms: | MAP Kinase p38 beta | MK11_MOUSE | Mapk11 | Mitogen-activated protein kinase 11 | Mitogen-activated protein kinase p38 beta | Prkm11 | p38B | ||
Type: | Enzyme | ||
Mol. Mass.: | 41390.66 | ||
Organism: | Mus musculus (mouse) | ||
Description: | Q9WUI1 | ||
Residue: | 364 | ||
Sequence: |
| ||
Component 3 | |||
Name: | Mitogen-activated protein kinase 13 | ||
Synonyms: | MAP kinase 13 | MAP kinase p38 delta | MAPK 13 | MK13_MOUSE | Mapk13 | Mitogen-activated protein kinase 13 | Mitogen-activated protein kinase p38 delta | Serk4 | Stress-activated protein kinase 4 | ||
Type: | PROTEIN | ||
Mol. Mass.: | 42081.17 | ||
Organism: | Mus musculus | ||
Description: | ChEMBL_105000 | ||
Residue: | 366 | ||
Sequence: |
| ||
Component 4 | |||
Name: | Mitogen-activated protein kinase 14 | ||
Synonyms: | Crk1 | Csbp1 | Csbp2 | MAP Kinase p38 alpha | MAP kinase p38 | MK14_MOUSE | Mapk14 | Mitogen-activated protein kinase 14 | Mitogen-activated protein kinase p38 alpha | ||
Type: | Enzyme | ||
Mol. Mass.: | 41281.22 | ||
Organism: | Mus musculus (mouse) | ||
Description: | The full-length open reading frame of murine p38 alpha was cloned and expressed in E. coli.. Soluble murine p38R was extracted from cell pellets and purified using ion-exchange chromatography. | ||
Residue: | 360 | ||
Sequence: |
| ||
BDBM50219251 | |||
n/a | |||
Name | BDBM50219251 | ||
Synonyms: | CHEMBL423071 | ||
Type | Small organic molecule | ||
Emp. Form. | C29H29FN6O4 | ||
Mol. Mass. | 544.5768 | ||
SMILES | C[C@@]1(CO[C@@H](OC1)c1nc(c([nH]1)-c1ccnc(Nc2ccccc2)n1)-c1ccc(F)cc1)C(=O)N1CCOCC1 |wU:4.7,1.0,wD:1.36,(10.99,1.09,;10.19,-.24,;9.3,1.03,;7.76,.9,;7.1,-.5,;7.99,-1.76,;9.53,-1.65,;5.58,-.63,;4.85,-1.97,;3.33,-1.72,;3.12,-.17,;4.5,.49,;1.79,.59,;1.79,2.15,;.43,2.92,;-.9,2.13,;-.9,.59,;-2.24,-.21,;-3.6,.55,;-3.62,2.08,;-4.95,2.83,;-6.29,2.04,;-6.26,.51,;-4.91,-.24,;.43,-.17,;2.28,-2.84,;2.72,-4.31,;1.65,-5.43,;.17,-5.08,;-.88,-6.21,;-.27,-3.61,;.78,-2.49,;11.5,-1.04,;11.48,-2.61,;12.86,-.29,;14.19,-1.08,;15.53,-.31,;15.55,1.24,;14.22,2.03,;12.88,1.26,)| | ||
Structure |