| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
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| Ligand | BDBM50219824 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_157221 (CHEMBL769545) |
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| IC50 | 43±n/a nM |
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| Citation |  Billah, M; Buckley, GM; Cooper, N; Dyke, HJ; Egan, R; Ganguly, A; Gowers, L; Haughan, AF; Kendall, HJ; Lowe, C; Minnicozzi, M; Montana, JG; Oxford, J; Peake, JC; Picken, CL; Piwinski, JJ; Naylor, R; Sabin, V; Shih, NY; Warneck, JB 8-Methoxyquinolines as PDE4 inhibitors. Bioorg Med Chem Lett12:1617-9 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
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| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
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| Synonyms: | Dpde1 | PDE4C_RAT | Pde4c |
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| Type: | PROTEIN |
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| Mol. Mass.: | 60038.21 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_104732 |
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| Residue: | 536 |
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| Sequence: | NSSRTSSAASDLHGEDMIVTPFAQVLASLRTVRSNVAALAHGAGSATRQALLGTPPQSSQ
QAAPAEESGLQLAQETLEELDWCLEQLETLQTRRSVGEMASNKFKRMLNRELTHLSETSR
SGNQVSEYISQTFLDQQAEVELPAPPTEDHPWPMAQITGLRKSCHTSLPTAAIPRFGVQT
DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAVIFRVLQERDLLKTFQIPADTLLRYL
LTLEGHYHSNVAYHNSIHAADVVQSAHVLLGTPALEAVFTDLEVLAAIFACAIHDVDHPG
VSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQGENCDIFQNLSTKQKLSLRRMVID
MVLATDMSKHMSLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQSLVHCADLSNPAKPL
PLYRQWTERIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWAD
LVHPDAQELLDTLEDNREWYQSRVPCSPPHAIGPDRFKFELTLEETEEEEEEDERH
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| BDBM50219824 |
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| n/a |
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| Name | BDBM50219824 |
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| Synonyms: | CHEMBL444824 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H10Cl2N4O2 |
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| Mol. Mass. | 373.193 |
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| SMILES | COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2ccc(nc12)C#N |
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| Structure | 
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