| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
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| Ligand | BDBM50219830 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_157365 (CHEMBL762041) |
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| IC50 | 38±n/a nM |
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| Citation |  Billah, M; Cooper, N; Cuss, F; Davenport, RJ; Dyke, HJ; Egan, R; Ganguly, A; Gowers, L; Hannah, DR; Haughan, AF; Kendall, HJ; Lowe, C; Minnicozzi, M; Montana, JG; Naylor, R; Oxford, J; Peake, JC; Piwinski, JJ; Runcie, KA; Sabin, V; Sharpe, A; Shih, NY; Warneck, JB Synthesis and profile of SCH351591, a novel PDE4 inhibitor. Bioorg Med Chem Lett12:1621-3 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
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| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
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| Synonyms: | Dpde1 | PDE4C_RAT | Pde4c |
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| Type: | PROTEIN |
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| Mol. Mass.: | 60038.21 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_104732 |
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| Residue: | 536 |
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| Sequence: | NSSRTSSAASDLHGEDMIVTPFAQVLASLRTVRSNVAALAHGAGSATRQALLGTPPQSSQ
QAAPAEESGLQLAQETLEELDWCLEQLETLQTRRSVGEMASNKFKRMLNRELTHLSETSR
SGNQVSEYISQTFLDQQAEVELPAPPTEDHPWPMAQITGLRKSCHTSLPTAAIPRFGVQT
DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAVIFRVLQERDLLKTFQIPADTLLRYL
LTLEGHYHSNVAYHNSIHAADVVQSAHVLLGTPALEAVFTDLEVLAAIFACAIHDVDHPG
VSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQGENCDIFQNLSTKQKLSLRRMVID
MVLATDMSKHMSLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQSLVHCADLSNPAKPL
PLYRQWTERIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWAD
LVHPDAQELLDTLEDNREWYQSRVPCSPPHAIGPDRFKFELTLEETEEEEEEDERH
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| BDBM50219830 |
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| n/a |
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| Name | BDBM50219830 |
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| Synonyms: | CHEMBL42387 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H10F5N3O2 |
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| Mol. Mass. | 383.2722 |
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| SMILES | COc1ccc(C(=O)Nc2c(F)cncc2F)c2ccc(nc12)C(F)(F)F |
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| Structure | 
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