| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
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| Ligand | BDBM50219014 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_157225 (CHEMBL769549) |
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| IC50 | 28±n/a nM |
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| Citation |  Buckley, GM; Cooper, N; Davenport, RJ; Dyke, HJ; Galleway, FP; Gowers, L; Haughan, AF; Kendall, HJ; Lowe, C; Montana, JG; Oxford, J; Peake, JC; Picken, CL; Richard, MD; Sabin, V; Sharpe, A; Warneck, JB 7-Methoxyfuro[2,3-c]pyridine-4-carboxamides as PDE4 inhibitors: a potential treatment for asthma. Bioorg Med Chem Lett12:509-12 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
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| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
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| Synonyms: | Dpde1 | PDE4C_RAT | Pde4c |
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| Type: | PROTEIN |
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| Mol. Mass.: | 60038.21 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_104732 |
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| Residue: | 536 |
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| Sequence: | NSSRTSSAASDLHGEDMIVTPFAQVLASLRTVRSNVAALAHGAGSATRQALLGTPPQSSQ
QAAPAEESGLQLAQETLEELDWCLEQLETLQTRRSVGEMASNKFKRMLNRELTHLSETSR
SGNQVSEYISQTFLDQQAEVELPAPPTEDHPWPMAQITGLRKSCHTSLPTAAIPRFGVQT
DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAVIFRVLQERDLLKTFQIPADTLLRYL
LTLEGHYHSNVAYHNSIHAADVVQSAHVLLGTPALEAVFTDLEVLAAIFACAIHDVDHPG
VSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQGENCDIFQNLSTKQKLSLRRMVID
MVLATDMSKHMSLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQSLVHCADLSNPAKPL
PLYRQWTERIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWAD
LVHPDAQELLDTLEDNREWYQSRVPCSPPHAIGPDRFKFELTLEETEEEEEEDERH
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| BDBM50219014 |
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| n/a |
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| Name | BDBM50219014 |
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| Synonyms: | CHEMBL149559 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H11Cl2F2N3O4 |
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| Mol. Mass. | 418.179 |
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| SMILES | CCc1cc2c(cnc(OC(F)F)c2o1)C(=O)Nc1c(Cl)c[n+]([O-])cc1Cl |
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| Structure | 
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